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. 2010 Apr 19;285(26):19947–19958. doi: 10.1074/jbc.M110.111286

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Tether length differential potency and voltage dependence of bis(n)-cognitins. A, the graph shows the inhibitory effects of memantine, tacrine, and bis(n)-cognitins (B2C, B3C, B5C, B7C, and B10C) on 30 μm NMDA-activated currents at a holding potential of −50 mV in cultured rat hippocampal neurons. Each point represents the mean of percentage inhibition from 5–7 neurons. The IC₅₀ values are indicated in the graph. Inset, molecular structure of bis(propyl)-cognitin. B, voltage dependence of tacrine and bis(n)-cognitin blockade of NMDA-activated currents is analyzed by plotting the mean of percentage inhibition against holding potentials.