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. 2010 Apr 19;285(26):19947–19958. doi: 10.1074/jbc.M110.111286

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Onset and offset time constants of bis(propyl)-cognitin inhibition. A, traces show currents activated by 30 μm NMDA and its inhibition by 1 μm bis(propyl)-cognitin applied after the activation of NMDA receptors. The periods of drug application are indicated by the solid bar above the trace. White dotted lines drawn through the current trace (black part) are the theoretical fit of onset (τ_on) and offset (τ_off) of bis(propyl)-cognitin inhibition using single exponential functions. B, graph plotting average τ_on (■) and τ_off (●) values against bis(propyl)-cognitin concentration shows the concentration dependence of onset and offset kinetics. Error bars, S.E.