FIGURE 3.

Resistance of XIAP-deficient mice for LPS-induced experimental endotoxin shock. A, both WT and XIAP KO mice were challenged with the LD₁₀₀ of LPS (0.5 mg/kg body weight) intraperitoneally, and the survival of WT and XIAP KO mice was monitored over the period of 4 days. Shown is the representative result of one of three independent experiments. B, survival of mice after intravenous infection with S. typhimurium is shown. Survival of WT and XIAP KO was monitored for 1 week after infection. All mice were dead 6 days post-infection without any significant difference in WT or XIAP KO mice.