Table 1.
Comparison of the relative frequencies of the FMR1 alleles with CGG repeat expansions within the PM range (55-200 CGGs), and GZ range (40-54 CGGs), between samples of combined Victorian and Tasmanian cases1 and Tasmanian cases alone,2 and control sample, using Fisher’s exact test. The odds ratio (OR) and confidence intervals (CI) estimated using univariate logistic regression are also shown.
| Cases | Controls | Fisher’s test | Logistic regression | |||||
|---|---|---|---|---|---|---|---|---|
| CGG category | n | (%) | n | % | P-value | OR | 95% CI | P-value |
| 1Premutation- | 224 | (98.50) | 576 | (100) | ||||
| Premutation+ | 4 | (1.75) | 0 | (0) | 0.006 | NA | NA | NA |
| 1Grey zone- | 211 | (92.54) | 557 | (96.70) | ||||
| Grey zone+ | 17 | (7.46) | 19 | (3.30) | 0.014 | 2.36 | 1.20-4.63 | 0.012 |
| 2Grey zone- | 126 | (92.95) | 557 | (96.70) | ||||
| Grey zone+ | 10 | (7.35) | 19 | (3.30) | 0.049 | 2.33 | 1.06-5.13 | 0.036 |
All P-values reported in the Table were 2-sided. 1-sided P-value of Fisher’s test for PM category was 0.006; for GZ category it was 0.011 for combined sample, and 0.034, for Tasmanian sample only.
1
Tasmanian and Victorian cases combined.
2
Tasmanian cases only