Table 2.
Comparison of average dose–volume histograms of clinically accepted IMRT plan and 18F-FMISO–guided IMRT plan
| Clinically accepted IMRT plan/18F-FMISO–guided IMRT plan | ||||
|---|---|---|---|---|
| Structure | Dmax (Gy) | D05 (Gy) | D95 (Gy) | Dmean (Gy) |
| PTVp84 | —/92 ± 1 | —/91 ± 2 | —/84 ± 0.7 | —/88 ± 1 |
| PTV70 | 78 ± 2/91 ± 2 | 75 ± 2/81 ± 2 | 70 ± 2/70 ± 0.01 | 73 ± 1/75 ± 0.9 |
| PTV59.4 | 76 ± 2/82 ± 5 | 69 ± 4/72 ± 2 | 59 ± 2/59 ± 0.7 | 64 ± 1/65 ± 1 |
| PTV54 | 66 ± 5/68 ± 8 | 60 ± 0.9/61 ± 2 | 54 ± 0.8/53 ± 1 | 57 ± 0.6/57 ± 1 |
| Cord | 44 ± 0.9/44 ± 1 | 41 ± 1/40 ± 2 | 30 ± 5/30 ± 4 | |
| Brain stem | 48 ± 3/46 ± 4 | 42 ± 3/41 ± 3 | 20 ± 4 /19 ± 4 | |
| Left cochlea | 40 ± 6/39 ± 8 | 37 ± 7/35 ± 7 | 29 ± 6/28 ± 7 | |
| Right cochlea | 39 ± 8/38 ± 8 | 36 ± 7/34 ± 8 | 30 ± 7/29 ± 7 | |
| Left plexus | 60 ± 3/62 ± 2 | 56 ± 2/58 ± 3 | 47 ± 8/49 ± 8 | |
| Right plexus | 62 ± 3/63 ± 3 | 56 ± 2/57 ± 3 | 46 ± 7/48 ± 9 | |
| Left parotid | 70 ± 6/71 ± 7 | 54 ± 7/54 ± 8 | 24 ± 2/24 ± 3 | |
| Right parotid | 68 ± 9/68 ± 9 | 56 ± 10/55 ± 11 | 26 ± 2/25 ± 4 | |
| Oral cavity | 67 ± 3/69 ± 3 | 58 ± 2/58 ± 3 | 37 ± 3/36 ± 2 | |
| Mandible | 67 ± 4/69 ± 4 | 60 ± 4/60 ± 4 | 36 ± 6 /36 ± 6 | |
Abbreviations: IMRT = intensity-modulate radiotherapy; 18F-FMISO = fluorine-18–labeled fluoromisonidazole; PTV70 = 70 Gy delivered to PTV of clinically defined GTV; PTVp84 = 84 Gy delivered to GTVh detected within primary GTV; PTVn84 = 84 Gy delivered to all GTVh detected within all nodal GTVs; other abbreviations as in Table 1.
Note, GTV for hypoxia-guided plan excluded GTVh.