n
|
63 |
Median age, years (range) |
9 (1–22) |
Gender: female/male |
25/38 |
Diagnoses |
Number of recipients |
Immunophenotypes |
|
Pre-B cell (1 patient infant MLL) |
51 |
T-cell |
12 |
High risk CR1 |
|
Primary induction failure (PIF) |
10 [3 also t(9;11)] |
t(9;11) |
7 (3 also PIF) |
Other [secondary ALL 1, |
4 |
patient; t(4;11) plus M2 at day 14, |
|
1 patient, high MRD+ after |
|
consolidation 2 patients] |
|
High risk CR2 |
|
BM relapse <18 months (5 T-cell, 1 MLL) |
8 |
BM relapse 18–36 months (3 T-cell) |
8 |
Intermediate risk CR2 |
|
BM relapse ≥36 months (all B-cell) |
12 |
Isolated-CNS relapse <18 |
5 |
months (2 T-cell, 3 B-cell) |
|
All patients beyond CR2 |
|
CR3 (11 patients), CR4 (1 patient) |
12 |
Stem cell source/HLA matching |
|
Related donor-bone marrow |
|
Fully matched sibling |
26 |
5/6 HLA matched sibling |
1 |
6/6 HLA matched parent |
1 |
Unrelated donor-bone marrow/PBSC |
|
10/10 HLA match |
3 |
9/10 HLA match |
2 |
Unrelated donor-cord blood |
|
6/6 HLA match |
1 |
5/6 HLA match |
19 |
4/6 HLA match |
9 |
3/6 HLA match |
1 |