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. Author manuscript; available in PMC: 2010 Jun 21.
Published in final edited form as: Arch Gen Psychiatry. 2009 Aug;66(8):811–822. doi: 10.1001/archgenpsychiatry.2009.91

Table 3.

Brain Regions With Significant Activation Within Healthy Control and Schizophrenic Patient Groups by Task

Brain Regiona Volume, mm3 Brodmann
Area
Talairach Coordinates,
x, y, z
N-Back in Controls
Right superior frontal gyrus 1600 6 2, 8, 48
Left middle frontal gyrus 4888 6 −42, 2, 40
720 10 −36, 40, 24
408 6 −22, −12, 52
Right middle frontal gyrus 1104 10 36, 44, 16
Right inferior frontal gyrus 2072 9 46, 14, 22
Right precentral gyrus 1072 6 32, −8, 54
Right anterior cingulate gyrus 952 32 2, 24, 38
Left inferior parietal lobule 3384 40 −38, −54, 38
Right precuneus 2360 19 32, −62, 38
Left cerebellum declive 3024 −36, −68, −14
Left cerebellum, cerebellar tonsil 608 −36, −54, −38
Right cerebellum declive 1048 30, −64, −16
Right cerebellum anterior lobe 832 32, −56, −28
568 0, −54, −28
Left claustrum 2240 −30, 20, 2
Left thalamus ventral anterior nucleus 1760 −12, −8, 12
Right thalamus 816 4, −22, 8

N-Back in Schizophrenic Patients
Left middle frontal gyrus 1616 6 −32, −2, 48
1568 9 −42, 14, 28
Right middle frontal gyrus 3272 9 46, 8, 34
Right anterior cingulate gyrus 1648 32 6, 18, 42
Right superior parietal lobule 1952 7 24, −64, 42
Left inferior parietal lobule 1240 40 −38, −48, −40
Right inferior parietal lobule 736 40 40, −46, 40
Left cerebellum declive 944 −36, −62, −16
672 −6, −72, −14
Right cerebellum culmen 1304 38, −52, −18
Left insula 664 13 −36, 14, −2

Delayed Match to Sample in Controls
Right middle frontal gyrus 840 11 28, 44, −10
Left inferior frontal gyrus 592 45 −40, 20, 4

Delayed Match to Sample in Schizophrenic Patients
Left middle frontal gyrus 728 46 −50, 28, 20
Right middle frontal gyrus 1000 9 36, 30, 28
Left inferior frontal gyrus 856 9 −58, 6, 22
Left superior parietal lobule 520 7 −36, −70, 46
Right insula 688 30, 22, 2

Go/No-Go in Controls
Left superior frontal gyrus 576 9 −28, 50, 34
Left middle frontal gyrus 648 9 −40, 14, 28
Right middle frontal gyrus 640 9 42, 22, 28
640 6 42, 6, 48
Right inferior frontal gyrus 448 13 36, 22, 6
Right precentral gyrus 552 9 40, 8, 36
Left postcentral gyrus 464 3 −42, −22, 40
Right postcentral gyrus 512 2 52, −22, 34
Left claustrum 544 −30, 14, 0
Right thalamus 736 14, −14, 2

Go/No-Go in Schizophrenic Patients
Left middle frontal gyrus 1776 9 −36, 12, 26
Right middle frontal gyrus 664 10 38, 36, 24
Right inferior frontal gyrus 792 9 40, 8, 30
Right anterior cingulate gyrus 712 32 2, 14, 38
Right inferior parietal lobule 752 40 42, −32, 38

Stroop in Controls
Left precentral gyrus 728 6 −42, 0, 34
Right anterior cingulate gyrus 464 32 2, 14, 40
Left middle temporal gyrus 1072 21 −58, −48, 6
Right supramarginal gyrus 680 40 54, −50, 24
Left precuneus 560 7 −24, −64, 30
416 7 −14, −66, 44
Right precuneus 680 31 26, −72, 18
Left claustrum 688 −28, 18, 4

Stroop in Schizophrenic Patients
Right middle frontal gyrus 1840 46 40, 28, 14
Right precentral gyrus 696 6 36, 2, 36
Left postcentral gyrus 528 5 −20, −42, 66
Right cuneus 1048 18 24, −76, 18
Right insula 464 13 32, 16, −6
Left thalamus 672 −12, −12, 2
a

Regions are listed in hierarchical order based on the following nested criteria: cortical to cerebellar to subcortical, rostral to caudal, dorsal to ventral, left to right, and large to small.