Table 2.
Association of plasma IL6 and CRP levels with presence of white matter lesions and brain infarcts at the 1st MRI examination
| Odds Ratio (95% Confidence Interval) for association with presence of WML | Odds Ratio (95% Confidence Interval) for association with presence of BI | |||||||
|---|---|---|---|---|---|---|---|---|
| Whites (N=3,073) | Blacks (N=571) | Whites (N=3,073) | Blacks (N=571) | |||||
| IL6 | CRP | IL6 | CRP | IL6 | CRP | IL6 | CRP | |
| Model 1 | ||||||||
| 1st Quartile | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) |
| 2nd Quartile | 1.24 (0.99; 1.55) | 1.28 (1.03; 1.59) | 1.87 (1.09; 3.19) | 0.82 (0.49; 1.38) | 1.38 (1.07; 1.78) | 0.99 (0.78; 1.25) | 1.05 (0.57; 1.92) | 1.05 (0.58; 1.89) |
| 3rd Quartile | 1.32 (1.05; 1.65) | 1.31 (1.05; 1.62) | 1.26 (0.75; 2.13) | 0.89 (0.53; 1.51) | 1.43 (1.10; 1.85) | 1.16 (0.92; 1.47) | 1.17 (0.63; 2.17) | 1.07 (0.60; 1.93) |
| 4th Quartile | 1.48 (1.18; 1.86) | 1.59 (1.27; 1.98) ** | 2.16 (1.26; 3.73) * | 1.28 (0.74; 2.19) | 1.81 (1.40; 2.33)** | 1.18 (0.93; 1.49) | 1.37 (0.74; 2.51) | 1.45 (0.81; 2.58) |
| P trend | 0.007 | 0.0006 | 0.02 | 0.37 | 0.0001 | 0.29 | 0.74 | 0.56 |
| Per SD (log) | 1.28 (1.11; 1.47) | 1.13 (1.06; 1.22) | 1.55 (1.12; 2.15) | 1.09 (0.93; 1.28) | 1.41 (1.21; 1.63) | 1.11 (1.03; 1.20) | 1.32 (0.94; 1.85) | 1.16 (0.98; 1.38) |
| Model 2 | ||||||||
| 1st Quartile | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) |
| 2nd Quartile | 1.22 (0.97; 1.53) | 1.21 (0.97; 1.51) | 1.83 (1.05; 3.18) | 0.80 (0.47; 1.37) | 1.35 (1.04; 1.75) | 0.95 (0.74; 1.21) | 1.09 (0.58; 2.04) | 1.04 (0.56; 1.93) |
| 3rd Quartile | 1.27 (1.01; 1.60) | 1.20 (0.97; 1.50) | 1.25 (0.71; 2.17) | 0.86 (0.50; 1.48) | 1.40 (1.07; 1.83) | 1.10 (0.86; 1.41) | 1.12 (0.58; 2.18) | 1.11 (0.60; 2.04) |
| 4th Quartile | 1.43 (1.12; 1.82) * | 1.48 (1.17; 1.84) ** | 2.20 (1.23; 3.90) * | 1.16 (0.67; 2.04) | 1.75 (1.34; 2.28)** | 1.11 (0.86; 1.42) | 1.37 (0.71; 2.65) | 1.62 (0.85; 3.11) |
| P trend | 0.03 | 0.01 | 0.03 | 0.55 | 0.0008 | 0.54 | 0.80 | 0.43 |
| Per SD (log) | 1.24 (1.07; 1.44) | 1.11 (1.03; 1.19) | 1.55 (1.10; 2.19) | 1.06 (0.90; 1.25) | 1.37 (1.17; 1.60) | 1.09 (1.01; 1.19) | 1.34 (0.93; 1.93) | 1.21 (1.00; 1.47) |
| Model 3 | ||||||||
| 1st Quartile | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) | 1 (referent) |
| 2nd Quartile | 1.09 (0.84; 1.41) | 1.15 (0.89; 1.50) | 1.95 (1.02; 3.71) | 0.84 (0.44; 1.61) | 1.33 (0.99; 1.80) | 0.96 (0.72; 1.29) | 1.28 (0.62; 2.67) | 0.81 (0.39; 1.66) |
| 3rd Quartile | 1.28 (0.97; 1.67) | 1.13 (0.86; 1.47) | 1.22 (0.63; 2.34) | 0.83 (0.43; 1.58) | 1.38 (1.01; 1.87) | 1.07 (0.80; 1.44) | 1.19 (0.56; 2.56) | 1.03 (0.51; 2.08) |
| 4th Quartile | 1.42 (1.08; 1.87)* | 1.33 (1.01; 1.75)* | 2.13 (1.08; 4.20)* | 0.90 (0.44; 1.86) | 1.87 (1.38; 2.54)** | 1.14 (0.84; 1.54) | 1.68 (0.81; 3.52) | 1.47 (0.70; 3.08) |
| P trend | 0.06 | 0.26 | 0.06 | 0.94 | 0.0009 | 0.69 | 0.55 | 0.47 |
| Per SD (log) | 1.23 (1.05; 1.46) | 1.09 (0.99; 1.21) | 1.54 (1.03; 2.30) | 1.18 (0.94; 1.48) | 1.46 (1.22; 1.74) | 1.09 (0.99; 1.21) | 1.42 (0.96; 2.11) | 1.18 (0.94; 1.48) |
P<0.05;
P<0.01 for comparison with 1st quartile;
P trend over quartiles; SD: standard deviation; log: logarithm-transformed biomarker plasma levels; Model 1: adjusted for age and sex; Model 2: adjusted for age, sex, current smoking, education, diastolic blood pressure, body mass index, and hypertension (MRI-defined WML); adjusted for age, sex, current smoking, systolic blood pressure, diastolic blood pressure, HDL cholesterol, body mass index, diabetes, and hypertension (MRI-defined BI). Model 3: adjusted for variables in Model 2 and excluding individuals with prevalent stroke, transient ischemic attack, coronary heart disease, and heart failure (N=2,283, Whites; N=426, Blacks). Cutoff for Quartiles of plasma IL6 in Whites and Blacks, respectively: 1st: 0.35–1.08; 0.36–1.18 pg/mL; 2nd: 1.09–1.55; 1.19–1.70 pg/mL; 3rd: 1.56–2.31; 1.71–2.58 pg/mL; 4th: 2.32–44.17; 2.59–23.37 pg/mL. Cutoff for Quartiles of plasma CRP in Whites and Blacks, respectively: 1st: 0.13–1.13; 0.16–1.47 mg/L; 2nd: 1.14–2.43; 1.49–3.45 mg/L; 3rd: 2.44–5.34; 3.46–7.86 mg/L; 4th: 5.35–143.0; 7.89–79.40 mg/L.