Table 3.

Association of IL6 haplotypes and genotypes with presence of MRI-defined WML in Whites.

		SNP
		1111	1510	3572	6021	7592
Haplotype Index	Haplo. Freq.						OR* (95% CI)	P†	Global P†
1	40.5	G	C	T	C	A	1.14 (1.02; 1.28)	0.03	0.07
2	3.1	C	G	G	C	C	0.98 (0.72; 1.33)	0.91
3	23.2	G	G	G	C	A	0.93 (0.81; 1.07)	0.32
4	27.7	G	G	G	C	C	0.98 (0.86; 1.12)	0.68
OR ‡ (95% CI)		0.89 (0.69; 1.15)	1.13 (1.01; 1.27)	1.10 (0.99; 1.23)	0.84 (0.60; 1.18)	0.97 (0.86; 1.10)
P¶		0.13	0.03	0.08	0.46	0.58
Global P	0.03

^*Odds ratio per copy of haplotype adjusted for age, sex, current smoking, education, diastolic blood pressure, body mass index, and hypertension.

^†Permutation-based P value from score test. P values for individual haplotypes test the null hypothesis that the odds of having WML of a particular haplotype are the same as that of all other haplotypes combined. The global P value tests the null hypothesis that the odds of having WML are the same for all haplotypes.

^‡Odds ratio per copy of variant allele adjusted for age, sex, current smoking, education, diastolic blood pressure, body mass index, and hypertension.

^¶adjusted for multiple tests.

Haplo. Freq.: Haplotype frequency. SNP: Single nucleotide polymorphism