Table 4.

Association of IL6 haplotypes and genotypes with presence of MRI-defined BI in Whites.

		SNP
		1111	1510	3572	6021	7592
Haplotype Index	Haplo. Freq.						OR* (95% CI)	P†	Global P†
1	40.5	G	C	T	C	A	1.02 (0.90; 1.16)	0.78	0.01
2	3.1	C	G	G	C	C	1.57 (1.15; 2.14)	0.001
3	23.2	G	G	G	C	A	0.98 (0.85; 1.13)	0.76
4	27.7	G	G	G	C	C	0.97 (0.84; 1.12)	0.70
OR ‡ (95% CI)		1.23 (0.94; 1.62)	1.02 (0.90; 1.15)	1.01 (0.89; 1.14)	0.90 (0.61; 1.32)	0.98 (0.85; 1.13)
P ¶		0.13	0.48	0.51	0.53	0.87
Global P	0.61

^*Odds ratio per copy of haplotype adjusted for age, sex, current smoking, systolic blood pressure, diastolic blood pressure, HDL cholesterol, body mass index, diabetes, and hypertension.

^†Permutation-based P value from score test.

^‡Odds ratio per copy of variant allele adjusted for age, sex, current smoking, systolic blood pressure, diastolic blood pressure, HDL cholesterol, body mass index, diabetes, and hypertension.

^¶adjusted for multiple tests.

Haplo. Freq.: Haplotype frequency. SNP: Single nucleotide polymorphism