Table 2.

Global tolerances to large changes in parameter values for phenotypes 11 and 47 between the dashed lines in the design space of Fig. 3^*. The parameters on the left are involved in the synthesis and loss of mRNA; those on the right are involved in the synthesis, loss, and inter-conversion of protein molecules.

mRNA		Protein
Parameter	Tolerance	Parameter	Tolerance
γ M	[2.0, 4.2] †	δ C	[∞, 41]
γ M max	[2.4, 1.7]	δ C max	[1.7, 82]
KD	[2.8, 1.6]	KR	[82, ∞]
KI	[11, 2.4]	a	[5.6, ∞]
p	[3.0, 3.4]	γ C	[1.6, 1.7]
n	[∞,∞]	γ D	[1700, 2.8]
δ M	[1.7, 1.6]	β D	[3.4, 1900]
		δ D	[11, 1.6]

^†[fold decrease, fold increase]

^*Note that in Fig. 3 the upper boundaries of Regions 11 and 47 extend to the upper boundary of Region 7 and the c-d boundary of Region 43, respectively.