Figure 4. Deletion of REG1 alters the subcellular distribution of glycogen synthase.
Deletion of the REG1 gene results in increased glycogen storage but does not alter the phosphorylation state of glycogen synthase. A strain in which REG1 had been deleted (DH11-51) was transformed with wild type Gsy2-GFP (pWW214) and grown overnight in SC-Trp medium. The localization pattern of Gsy2-GFP was scored by fluorescence microscopy as described in the legend to Figure 2 and the wild type cells were strain EG328-1A (Panel A). Representative images are shown (Panel B). The left-hand image shows a field of cells observed using differential interference contrast. The right-hand panel shows fluorescence images of the same fields. In reg1 mutant cells, Gsy2-GFP had a more diffuse distribution than in wild type cells. The scale bar represents 10 μm.