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. 2010 Mar 31;103(6):3516–3525. doi: 10.1152/jn.00982.2009

Fig. 4.

Fig. 4.

Reduction of outward currents in Kv3.3 KO patches. A–D: voltage-dependent currents in response to 10 mV step depolarizations from −80 to +40 mV from outside-out somatic patches from wild-type and Kv3.3 KO PCs. Large outward currents in patches from wild-type PCs (A) were significantly reduced on application of 1 mM TEA (B). C: subtraction of B from A shows currents sensitive to 1 mM TEA. D: voltage clamp recordings from a Kv3.3 KO somatic outside-out patch showing highly reduced outward currents. Scale bars in A refer to traces in A-D. E: box plot of peak currents at +40 mV from wild-type (n = 7) and Kv3.3 KO (n = 5) recordings. F: normalized conductance-voltage curve for TEA-sensitive currents from wild-type PCs (n = 6). Gray line is a Boltzmann fit: V1/2, −4.3 mV; k, 12.2. Error bars are SD.