Table 2.
Association of MAOA, 5-HTT, and NET genotypes with transcription levels and protein activities in human placentas
| Genotypes | Relative mRNA Levels, mean ± SE | Protein Activities, mean ± SE |
|---|---|---|
| MAOA uVNTR | MAOA/ACTB | Enzyme activity, units/g protein |
| 3-repeat | 0.85 ± 0.07 (n = 12 males) | 11.20 ± 0.28 (n = 12 males) |
| 3-repeat/3-repeat | 0.80 ± 0.12 (n = 5 females) | 11.17 ± 0.41 (n = 5 females) |
| 4-repeat | 1.21 ± 0.05 (n = 22 males) | 11.78 ± 0.20 (n = 22 males) |
| 4-repeat/4-repeat | 1.01 ± 0.12 (n = 11 females) | 11.12 ± 0.11 (n = 11 females) |
| 3-repeat +3-repeat/3-repeat | 0.84 ± 0.06 (n = 17) | 11.19 ± 0.22 (n = 17) |
| vs. | ||
| 4-repeat +4-repeat/4-repeat | 1.14 ± 0.05 (n = 33) | 11.56 ± 0.14 (n = 33) |
| t = 3.44, df = 48, P = 0.001 | t = 1.42, df = 48, P = 0.161 | |
| 5-HTT 5-HTTLPR | 5-HTT /ACTB | 5-HT uptake rate, pmol/mg protein/15 s |
| S/S | 0.28 ± 0.01 (n = 20) | 1.53 ± 0.02 (n = 8) |
| vs. | ||
| S/l | 0.31 ± 0.02 (n = 28) | 1.55 ± 0.02 (n = 9) |
| t = 1.25, df = 46, P = 0.218 | t = 0.77, df = 15, P = 0.450 | |
| L/l | 0.65 ± 0.03 (n = 25) | 1.85 ± 0.01 (n = 4) |
| vs. | ||
| S/S+S/l | 0.29 ± 0.01 (n = 48) | 1.54 ± 0.01 (n = 17) |
| t = 14.29, df = 71, P < 0.001 | t = 9.66, df = 19, P < 0.001 | |
| NET AAGG4 | NET/ACTB | DA or NE uptake rate, pmol/mg protein/15 s |
| S4/S4 | 0.09 (n = 1) | N/A |
| S4/l4 | 0.22 ± 0.02 (n = 25) | 2.18 ± 0.05 (n = 7, DA uptake) |
| 4.00 ± 0.10 (n = 7, NE uptake) | ||
| L4/l4 | 0.53 ± 0.02 (n = 47) | 2.34 ± 0.03 (n = 14, DA uptake) |
| 4.29 ± 0.06 (n = 14, NE uptake) | ||
| S4/l4 vs. L4/l4 | t = 8.46, df = 70, P < 0.001 | t = 2.77, df = 19, P = 0.012 (DA) |
| t = 2.80, df = 19, P = 0.011 (NE) |