Time course of plasma levels of IL6, IL8, MCP1, MCP2, MIP1α, and MIP1β. Dots connected by solid line represent the time course for median protein concentration in plasma samples (in pg/ml). For MCP1, MCP2, MIP1α, and MIP1β, significantly enhanced protein expression was confirmed after 4 h of on-pump surgery, whereas no changes were observed following off-pump surgery. For IL-6 and IL-8, significantly enhanced protein expression was confirmed after 4 h of on-pump and off-pump surgeries. Results are shown as means (± SE). *P < 0.05 vs. preoperative, **P < 0.01 vs. preoperative.