Figure 5. A global affect of ADAR1 silencing on gene expression in hESCs.

44 h after transfections, RNA were derived from hESCs treated with ADAR1-siRNA or with non-target siRNA negative control and analyzed by oligonucleotide Microarray. Annotated genes whose expression level was changed at least at 1.5 fold as a result of ADAR1 silencing were categorized into functional groups. Prominent functional groups of genes which were overrepresented in the upregulated and/or downregulated genes are shown. One star indicates p-value<0.05. Two stars indicate p-value<0.001.