. 2010 Jun 21;5(6):e11240. doi: 10.1371/journal.pone.0011240

Table 2. The top five biological networks in bovine cumulus cell proteome.

Network IDs	Proteins in Network^a)	Score^b)	Focus Proteins	Top Functions
1	ACADM, ATP1A2, BCKDHA, C7ORF20, CAPNS1, CSPG4, DPYSL2, Enolase, ERK, ETFA (includes EG:2108), ETFB (includes EG:2109), FAU, FHIT, GAK, HSPE1, IPO7, LGI1, MAP1B, MFGE8, MPZL1, MVP, NUMA1, PELP1, POSTN, PRKCSH, Rab11, RAB11B, RAB1A, TUBA3C, TUBA4A, TUBB2C, Tubulin, ULBP3, ZP2, ZP3	43	31	Cell-To-Cell Signaling and Interaction, Reproductive system development and function
2	ACTR6, AK2, ANXA4, AP3D1, BRP44, CALU, EEF2, EEF1A1, EEF1A2, EEF1B2, EEF1D, FOS, Immunoproteasome Pa28/20s, NIPSNAP1, OPTN, Proteasome PA700/20s, Protein-synthesizing GTPase, *PSMA* , PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMB2, PSMB4, PSME1, PSME2, PTPRN, RPLP1, RPLP2, RPLP0 (includes EG:6175), RPS18, SEC23B, TKT, TUFM	41	31	Protein synthesis, Molecular transport, Nucleic acid metabolism
3	Adaptor protein 2, Ap1, AP1G1, BLVRA, BTF3, CD58, Ck2, Clathrin, CLTC, CSNK2A1, EIF5A, FKBP3, FKBP10, GTF2F1, HNRNPA2B1, HNRNPL, IGF2R, NUCKS1, Peptidylprolyl isomerase, Phosphatidylinositol4,5 kinase, PIN1, PIP4K2A, POLR3C, PPIB, PSMA3, RGS19, RPL5 (includes EG:6125), SSB (includes EG:6741), TF, TFR2, TFRC, TOP1, TUBB4, VPS35, WARS	38	29	Cellular function and maintenance, Small molecule biochemistry, Molecular transport
4	3-hydroxyacyl-CoA dehydrogenase, ACAT1, Acetyl-CoA C-acetyltransferas e, ATIC, B4GALT1, CYLD, DAD1, DDOST, Dolichyl-diphosphooligosaccharide-protein glycotransferase, ECH1, ECHS1, Enoyl-CoA hydratase, ENPP1, GOT, GOT2, HADHA, HADHB, HSD17B4, HSD17B10, NFkB (complex), NME2, OSTC, PDIA6, PGRMC1, PPARα-RXRα, PRDX4, RPN1, RPN2, SFXN1, SLC27A1, STK10, STT3A, TOMM20, TOMM40, TOMM70A	36	28	Lipid metabolism, Small molecule biochemistry, Post-translational modification
5	ALPL, ANP32B, C21ORF33, CBX2, CCND1, CCT8, CDC37, DDX3X, DHRS12, EIF3D, EIF4A2, EIF4ENIF1, ELAVL1, ENO3, H1F0, H3F3B, Hdac, Histone h3, Histone h4, HNRNPM, Importin beta, INHA, KPNB1, Mi2, NCAPD2, PNO1, RAN, SF3B1, SF3B3, SWI-SNF, Tcf/lef, THRAP3, TNPO1, VRK1, XPO1	36	28	Molecular Transport, RNA Trafficking

a) The focus proteins are indicated with gene names and shown in bold letters.

b) A score of >2 is considered statistically significant.