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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Neurobiol Aging. 2008 Nov 25;31(11):1991–2001. doi: 10.1016/j.neurobiolaging.2008.10.009

Table 2.

Associations between DTI indices and age based on region-of-interest (ROI) tests in native space of each subject. Findings from voxel-wise tests in normalized space are also listed, for comparison.

Selected ROIs ROI analysisap-value (coefficientb)
 Voxel-wise analysis
FA MD D⊥ D||
Genu of corpus callosum <0.001 (−1.45) 0.005 (1.57) <0.001 (4.19) n.s. (1.72) Concordant FA decrease and MD increase
Left internal capsule <0.001 (−1.16) n.s. (−0.06) 0.002 (1.11) n.s (−0.62) FA decrease without MD change
Left cingulum n.s. (−0.41) 0.009 (1.08) 0.03 (1.50) n.s. (1.64) MD increase without FA change
Right frontal white matter <0.001 (−2.31) 0.007 (1.58) <0.001 (1.97) n.s. (−1.29) Greater increase of D⊥ than D||
Right putamen <0.001 (1.29) n.s. (0.68) n.s. (0.28) <0.001 (1.78) Greater increase of D|| than D⊥

n.s.: no significant association with age.

a

ROI analysis by ANOVA with threshold for significant of p ≤ 0.05.

b

Coefficient from linear regression: a positive value indicates increased diffusion with age. The unit of coefficient for MD, D⊥ and D|| is: ×10−6 mm2/s/year.