Table 4.

Multivariable survival models for time to BOS and time to death with acute rejection episodes as time-dependent risk factors

	BOS: 383 subjects, 58 events		Death/Re-tx: 383 subjects, 51 events		BOS/Death/Re-tx: 383 subjects, 106 events
Risk factor vs. no rejection	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Risk following first A1	1.7 (0.64, 4.8)	0.28	0.82 (0.36, 1.9)	0.65	1.10 (0.57, 2.1)	0.78
Risk following first A2	2.4 (1.1, 5.1)	0.022	0.49 (0.21, 1.2)	0.11	1.09 (0.62, 1.9)	0.76
Risk following second A1	1.1 (0.25, 5.2)	0.86	1.10 (0.32, 3.7)	0.88	1.1 (0.43, 2.9)	0.80
Risk following second A2	4.1 (1.9, 9.0)	<0.001	0.74 (0.30, 1.9)	0.52	1.8 (1.01, 3.2)	0.046
Risk following second rejection, mixed rejection types	4.4 (2.2, 9.1)	<0.001	2.0 (1.00, 4.1)	0.048	2.7 (1.6, 4.6)	<0.001

BOS, bronchiolitis obliterans syndrome; Re-tx, re-transplantation