Table 2.
Characteristics of Hodgkin lymphoma (HL) patients (N = 12,492) by age at diagnosis and race/ethnicity, California, 1988-2006.
Age 15-44 |
p- value |
Age ≥45 |
p- value |
|||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Race/ethnicity |
Race/ethnicity |
|||||||||||||||||
Characteristic | Non-Hispanic White |
Black | Hispanic | Asian/ Pacific Islander |
Non-Hispanic White |
Black | Hispanic | Asian/ Pacific Islander |
||||||||||
n=5584 | % | n=535 | % | n=1691 | % | N=418 | % | n=3004 | % | n=225 | % | n=822 | % | N=213 | % | |||
Sex | ||||||||||||||||||
Male | 2925 | 52.4 | 272 | 50.8 | 875 | 51.7 | 211 | 50.5 | 1683 | 56.0 | 117 | 52.0 | 492 | 59.9 | 138 | 64.8 | ||
Female | 2659 | 47.6 | 263 | 49.2 | 816 | 48.3 | 207 | 49.5 | 0.79 | 1321 | 44.0 | 108 | 48.0 | 330 | 40.2 | 75 | 35.2 | 0.01 |
Year of diagnosis | ||||||||||||||||||
1988-1992 | 1726 | 30.9 | 152 | 28.4 | 354 | 20.9 | 71 | 17.0 | 746 | 24.8 | 52 | 23.1 | 157 | 19.1 | 42 | 19.7 | ||
1993-1997 | 1467 | 26.3 | 146 | 27.3 | 405 | 24.0 | 82 | 19.6 | 757 | 25.2 | 60 | 26.7 | 188 | 22.9 | 52 | 24.4 | ||
1998-2002 | 1331 | 23.8 | 115 | 21.5 | 484 | 28.6 | 126 | 30.1 | 831 | 27.7 | 53 | 23.6 | 236 | 28.7 | 63 | 29.6 | ||
2003-2006 | 1060 | 19.0 | 122 | 22.8 | 448 | 26.5 | 139 | 33.3 | <0.001 | 670 | 22.3 | 60 | 26.7 | 241 | 29.3 | 56 | 26.3 | <0.001 |
Stage at diagnosis | ||||||||||||||||||
I | 807 | 14.5 | 79 | 14.8 | 227 | 13.4 | 61 | 14.6 | 593 | 19.7 | 41 | 18.2 | 149 | 18.1 | 49 | 23.0 | ||
II | 2688 | 48.1 | 216 | 40.4 | 744 | 44.0 | 214 | 51.2 | 868 | 28.9 | 57 | 25.3 | 198 | 24.1 | 50 | 23.5 | ||
III/IV | 1753 | 31.4 | 206 | 38.5 | 611 | 36.1 | 128 | 30.6 | 1301 | 43.3 | 107 | 47.6 | 415 | 50.5 | 97 | 45.5 | ||
Missing/unknown | 336 | 6.0 | 34 | 6.4 | 109 | 6.5 | 15 | 3.6 | <0.001 | 242 | 8.1 | 20 | 8.9 | 60 | 7.3 | 17 | 8.0 | 0.03 |
B-Symptoms | ||||||||||||||||||
No | 2003 | 35.9 | 177 | 33.1 | 563 | 33.3 | 185 | 44.3 | 981 | 32.7 | 73 | 32.4 | 232 | 28.2 | 75 | 35.2 | ||
Yes | 1756 | 31.5 | 178 | 33.3 | 673 | 39.8 | 140 | 33.5 | 970 | 32.3 | 90 | 40.0 | 339 | 41.2 | 72 | 33.8 | ||
Missing/unknown | 1825 | 32.7 | 180 | 33.6 | 455 | 26.9 | 93 | 22.3 | <0.001 | 1053 | 35.1 | 62 | 27.6 | 251 | 30.5 | 66 | 31.0 | <0.001 |
Histologic subtype | ||||||||||||||||||
Nodular sclerosis | 4377 | 78.4 | 375 | 70.1 | 1197 | 70.8 | 321 | 76.8 | 1441 | 48.0 | 90 | 40.0 | 305 | 37.1 | 93 | 43.7 | ||
Mixed cellularity | 550 | 9.9 | 74 | 13.8 | 242 | 14.3 | 41 | 9.8 | 749 | 24.9 | 60 | 26.7 | 278 | 33.8 | 70 | 32.9 | ||
Lymphocyte depletion |
53 | 1.0 | 4 | 0.8 | 28 | 1.7 | 3 | 0.7 | 115 | 3.8 | 12 | 5.3 | 36 | 4.4 | 7 | 3.3 | ||
Lymphocyte rich | 109 | 2.0 | 29 | 5.4 | 55 | 3.3 | 11 | 2.6 | 142 | 4.7 | 15 | 6.7 | 30 | 3.7 | 10 | 4.7 | ||
Not otherwise specified | 495 | 8.9 | 53 | 9.9 | 169 | 10.0 | 42 | 10.1 | <0.001 | 557 | 18.5 | 48 | 21.3 | 173 | 21.1 | 33 | 15.5 | <0.001 |
First course of treatment |
||||||||||||||||||
Combined modality |
2081 | 37.3 | 132 | 24.7 | 551 | 32.6 | 180 | 43.1 | 528 | 17.6 | 28 | 12.4 | 106 | 12.9 | 36 | 16.9 | ||
Radiation only | 834 | 14.9 | 54 | 10.1 | 154 | 9.1 | 42 | 10.1 | 408 | 13.6 | 23 | 10.2 | 71 | 8.6 | 28 | 13.2 | ||
Chemotherapy only |
2128 | 38.1 | 279 | 52.2 | 802 | 47.4 | 168 | 40.2 | 1531 | 51.0 | 137 | 60.9 | 451 | 54.9 | 100 | 47.0 | ||
None/unknown | 541 | 9.7 | 70 | 13.1 | 184 | 10.9 | 28 | 6.7 | <0.001 | 537 | 17.9 | 37 | 16.4 | 194 | 23.6 | 49 | 23.0 | <0.001 |
Neighborhood socioeconomic status (quintiles) |
||||||||||||||||||
1 (Lowest) | 381 | 6.8 | 156 | 29.2 | 526 | 31.1 | 28 | 6.7 | 272 | 9.1 | 78 | 34.7 | 268 | 32.6 | 27 | 12.7 | ||
2 | 906 | 16.2 | 144 | 26.9 | 456 | 27.0 | 60 | 14.4 | 515 | 17.1 | 56 | 24.9 | 204 | 24.8 | 36 | 16.9 | ||
3 | 1264 | 22.6 | 107 | 20.0 | 302 | 17.9 | 78 | 18.7 | 639 | 21.3 | 38 | 16.9 | 152 | 18.5 | 40 | 18.8 | ||
4 | 1510 | 27.0 | 86 | 16.1 | 253 | 15.0 | 119 | 28.5 | 738 | 24.6 | 27 | 12.0 | 110 | 13.4 | 47 | 22.1 | ||
5 (Highest) | 1523 | 27.3 | 42 | 7.9 | 154 | 9.1 | 133 | 31.8 | 840 | 28.0 | 26 | 11.6 | 88 | 10.7 | 63 | 29.6 | ||
Vital status | ||||||||||||||||||
Alive | 4852 | 86.9 | 419 | 78.3 | 1431 | 84.6 | 377 | 90.2 | 1327 | 44.2 | 116 | 51.6 | 366 | 44.5 | 107 | 50.2 | ||
Death from HL | 382 | 6.8 | 64 | 12.0 | 156 | 9.2 | 26 | 6.2 | 697 | 23.2 | 58 | 25.8 | 207 | 25.2 | 48 | 22.5 | ||
Death from Non- Hodgkin lymphoma or Leukemia |
56 | 1.0 | 14 | 2.6 | 18 | 1.1 | 2 | 0.5 | 214 | 7.1 | 7 | 3.1 | 66 | 8.0 | 14 | 6.6 | ||
Death from other cancer |
50 | 0.9 | 4 | 0.8 | 6 | 0.4 | 1 | 0.2 | 152 | 5.1 | 11 | 4.9 | 26 | 3.2 | 12 | 5.6 | ||
Death from circulatory disease |
42 | 0.8 | 6 | 1.1 | 14 | 0.8 | 4 | 1.0 | 225 | 7.5 | 11 | 4.9 | 48 | 5.8 | 9 | 4.2 | ||
Death from other cause |
125 | 2.2 | 18 | 3.4 | 39 | 2.3 | 4 | 1.0 | 288 | 9.6 | 15 | 6.7 | 77 | 9.3 | 16 | 7.5 | ||
Death from unknown cause |
77 | 1.4 | 10 | 1.9 | 27 | 1.6 | 4 | 1.0 | <0.001 | 101 | 3.4 | 7 | 3.1 | 32 | 3.9 | 7 | 3.3 | 0.07 |