Table 4.
Multivariate adjusted* hazard ratios and 95% confidence interval (95% CI) estimates for death from all causes (overall survival) and death from Hodgkin lymphoma (HL-specific survival) in HL patients diagnosed between 1988 and 2006 in the state of California by age group, stage of disease at diagnosis, race/ethnicity and neighborhood socioeconomic status (SES).
| Stage of disease at diagnosis | Age 15 - 44 years | Age ≥ 45 years | ||||||
|---|---|---|---|---|---|---|---|---|
| Overall Survival | HL-Specific Survival |
Overall Survival | HL-Specific Survival |
|||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| Stage I | ||||||||
| Race/ethnicity# | ||||||||
| Black | 1.52 | 0.80-2.89 | 1.96 | 0.73-5.26 | 1.23 | 0.76-2.01 | 2.02 | 0.90-4.54 |
| Hispanic | 0.82 | 0.46-1.45 | 1.70 | 0.84-3.46 | 1.08 | 0.81-1.43 | 1.44 | 0.87-2.37 |
| Asian/Pacific Islander | 1.21 | 0.48-3.03 | 1.15 | 0.27-4.91 | 0.83 | 0.53-1.29 | 0.69 | 0.25-1.93 |
| Neighborhood socioeconomic status group** | ||||||||
| Lower SES (Q+1-3) | 2.03 | 1.36-3.05 | 1.26 | 0.69-2.29 | 1.33 | 1.08-1.64 | 1.22 | 0.81-1.85 |
| Stage II | ||||||||
| Race/ethnicity# | ||||||||
| Black | 1.83 | 1.30-2.59 | 1.65 | 1.04-2.63 | 0.90 | 0.58-1.39 | 0.99 | 0.50-1.96 |
| Hispanic | 1.30 | 1.01-1.67 | 1.05 | 0.74-1.49 | 0.94 | 0.74-1.20 | 1.17 | 0.82-1.68 |
| Asian/Pacific Islander | 1.01 | 0.60-1.70 | 1.35 | 0.75-2.44 | 1.21 | 0.77-1.91 | 1.57 | 0.82-3.01 |
| Neighborhood socioeconomic status group** | ||||||||
| Lower SES (Q+1-3) | 1.56 | 1.26-1.92 | 1.96 | 1.47-2.62 | 1.35 | 1.12-1.62 | 1.39 | 1.04-1.87 |
| Stage III/IV | ||||||||
| Race/ethnicity# | ||||||||
| Black | 1.58 | 1.18-2.12 | 1.73 | 1.19-2.52 | 1.12 | 0.85-1.47 | 1.46 | 1.03-2.06 |
| Hispanic | 1.37 | 1.11-1.70 | 1.64 | 1.26-2.14 | 1.25 | 1.09-1.44 | 1.18 | 0.96-1.43 |
| Asian/Pacific Islander | 1.15 | 0.73-1.81 | 1.22 | 0.68-2.19 | 1.07 | 0.81-1.40 | 1.18 | 0.82-1.69 |
| Neighborhood socioeconomic status group** | ||||||||
| Lower SES (Q+1-3) | 1.28 | 1.06-1.54 | 1.21 | 0.95-1.54 | 1.27 | 1.13-1.43 | 1.19 | 1.01-1.40 |
| Unknown stage | ||||||||
| Race/ethnicity# | ||||||||
| Black | 2.50 | 1.19-5.26 | 4.01 | 1.41-11.38 | 1.14 | 0.56-2.31 | 2.14 | 0.79-5.81 |
| Hispanic | 2.40 | 1.40-4.14 | 2.58 | 1.09-6.11 | 0.83 | 0.53-1.29 | 0.82 | 0.37-1.82 |
| Asian/Pacific Islander | - | - | - | - | 0.57 | 0.26-1.24 | 0.41 | 0.09-1.77 |
| Neighborhood socioeconomic status group** | ||||||||
| Lower SES (Q+1-3) | 1.25 | 0.79-1.99 | 0.92 | 0.46-1.83 | 1.17 | 0.86-1.61 | 1.43 | 0.82-2.47 |
*
Adjusted for age at diagnosis (continuous), sex, year of diagnosis (1988-92, 1993-1997, 1998-2002, 2003-6) presence of B-symptoms (yes, no, unknown), histologic subtype (nodular sclerosis, mixed cellularity, lymphocyte depletion, lymphocyte rich, not otherwise specified).
+
Quintile
**
Reference group = Higher SES (Q 4,5).
#
Reference group = non-Hispanic white race/ethnicity.