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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nature. 2010 May 19;465(7300):885–890. doi: 10.1038/nature09121

Figure 1. Structure of the ternary Myddosome complex.

Figure 1

a, A ribbon diagram of the structure, with the 6 MyD88 molecules in cold colors, the 4 IRAK4 molecules in earth-tone colors and the 4 IRAK2 molecules in warm colors. b, Superposition of MyD88 DD (cyan), IRAK4 DD (yellow) and IRAK2 DD (magenta). Helices H1 to H6 and the H1-H2, H2-H3 and H4-H5 loops are labeled. c, Surface diagram of the complex with each subunit labeled using the same color coding as in a. M: MyD88; I4: IRAK4; I2: IRAK2. d, Planar arrangement of the complex. e, The helical symmetry is shown in a helical wheel representation with each ball representing a molecule and looking down the helical axis. Each molecule is labeled as an integer sequentially from M1 to I24.