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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Pathol Biol (Paris). 2010 Feb 8;58(4):258–266. doi: 10.1016/j.patbio.2009.11.001

Figure 2.

Figure 2

Noncytopathic clearance of HBV from the hepatocyte by T cell- derived cytokines. On antigen recognition, CD8-positive CTL deliver an apoptotic signal to their target cells, killing them. They also secrete IFNγ and TNF-α, cytokines that abolish viral replication and HBV gene expression in vivo, potentially curing them. Reprinted/amended from Am J Pathol 2000, 156:1117–1132 with permission from the American Society for Investigative Pathology.