Table 3.

Mean±SEM change in laboratory values by sex and bicarbonate treatment status^a

Number	Men			Women
	Control	Bicarbonate	P	Control	Bicarbonate	P
	35	36		49	42
24-h urine
Creatinine (Cr; mmol)	0.67±0.54	−0.27±0.53	0.225	0.55±0.24	0.71±0.26	0.671
Nitrogen/Cr (mmol/mmol)	−1.53±2.50	−2.58±2.50	0.767	2.50±2.02	−6.14±2.18	0.004
NAE/Cr (mmol/mmol)	−0.23±0.25	−2.87±0.25	<0.001	0.47±0.29	−4.11±0.31	<0.001
Potassium/Cr (mmol/mmol)	1.41±0.51	1.49±0.50	0.916	1.43±0.51	1.92±0.55	0.519
Sodium/Cr (mmol/mmol)	1.26±0.67	2.57±0.66	0.171	0.36±0.66	1.27±0.71	0.348
Serum
PTH (pmol/L)	−0.01±0.27	−0.36±0.27	0.377	−0.25±0.20	0.19±0.21	0.139
IGF-1 (nmol/L)	17.59 ±18.43	21.57±18.21	0.880	7.50±20.04b	9.10±21.49	0.959

^aChanges are adjusted for baseline laboratory value and changes in urinary sodium/Cr and urinary potassium/Cr.

^bN=48