Evaluation of remifentanil sevoflurane response surface models in patients emerging from anesthesia: Model improvement using effect-site sevoflurane concentrations

. Author manuscript; available in PMC: 2010 Aug 1.

Published in final edited form as: Anesth Analg. 2009 Oct 9;111(2):387–394. doi: 10.1213/ANE.0b013e3181afe31c

Table of inhalation agent pharmacokinetic model parameters.

Description	Abbreviation	Typical Value(Adjustment for Age, Weight, & Height)
Cardiac Output	Q	0.2 ^* wt^0.75
Pulmonary Blood Flow	Q_pulmt	0.95 ^* Q
Alveolar	Q_Alveolar
Intrapulmonary Shunt	Q_Shunt	0.05 ^* Q
Systemic Blood Flow
Visceral Organ Blood Flow
Heart	Q_Heart	0.05 ^* Q
Brain	Q_Brain	0.160 ^* Q
Kidneys	Q_Kidney	0.25 ^* Q
Liver	Q_Liver	0.3 ^* Q
Lean Organ Blood Flow
Muscles	Q_Muscle	0.13 ^* Q
Connective tissue	Q_Conn	0.06 ^* Q
*Adipose Blood Flow*	Q_Adipose	0.05 ^* Q
Systemic Tissue Volumes
Visceral Organs
Total Body Vol	V_BodyTotal	Weight
Heart	V_Heart	^{0.004 *} V_BodyTotal
Brain	V_Brain	^{0.0021 *} V_BodyTotal
Kidney	V_Kidney	^{0.004 *} V_BodyTotal
Liver	V_Liver	^{0.057 *} V_BodyTotal
*Lean Tissue*
Muscle	V_Muscle	^{0.426 *} V_BodyTotal
Connective tissue	V_Conn	^{0.260 *} V_BodyTotal
*Adipose Tissue*	V_Adipose	^{0.150 *} V_BodyTotal
Blood Volume Compartments
Total	V_total	0.07 ^* Weightt
Arterial pool	V_Arterial	0.2 ^* V_total
Venous pool in adipose tissue	V_Adipose	0.009 ^* V_total
Venous pool in lean tissue	V_Lean	0.291 ^* V_total
Venous pool in viscera	V_Viscera	0.319 ^* V_total
Central venous pool	V_CV	0.101 ^* V_total
Partition Coefficients
Blood:Gas	λ_Blood:Gas	0.69
Kidney	λ_Kidney	1.2
Heart	λ_Heart	1.7
Brain	λ_Brajn	1.7
Liver	λ_Liver	0.8
Muscle	λ_Muscle	3.1
Connective	λ_Connective	1.5
Adipose	λ_Adipose	48.0