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Synthesis of bicyclic hydroxy amides
| entry | amide | yield (%)a | major product | purity (%)b |
|---|---|---|---|---|
| 1 | 23{1} (R = C(H)Me2) | 86 | 29{1} | 100 |
| 2 | 23{4} (R = CH2OPh) | 92 | 29{2} | 96 |
| 3 | 23{6} (R = CH2PhOMe) | 92 | 29{3) | 95 |
| 4 | 23{8} (R = CH2PhF) | 91 | 29{4} | 97 |
| 5 | 26{1} (R = C(H)Me2) | 86 | 30{1} | 99 |
| 6 | 26{2} (R = C9H19) | 93 | 30{2} | 96 |
| 7 | 26{5} (R = CH2PhOMe) | 90 | 30{3} | 99 |
| 8 | 26{7} (R = CH2CH2Ph) | 42 | 30{4} | 100 |
Isolated yield.
UV purities determined at 214 nm after recrystallization.
