A1, B1, C1, Baseline (BL) freezing, tone CS freezing, trace CS freezing, and post-shock freezing (ISI) during training on trace fear conditioning was similar between young (2 mo and 4 mo) and middle-aged (8 mo) WT and 5XFAD mice. A2, B2, C2, Baseline (BL) freezing, retention of the tone CS memory (average of tone CS 1-4), and retention of the trace CS memory (average of trace CS intervals1-4) was comparable in WT and 5XFAD young (2 mo and 4 mo) and middle-aged (8 mo) mice.