Table 4.

Table 4a. Age-dependent association of selected INSIG2 tagSNPs with BMI in the total cohort by race.
African-Americans (N=2,129)
SNP	Reference	Difference^a in trait value (95% CI) at age 18 per copy of reference allele	P	Change^a in trait value (95% CI) par year of age per copy of reference allele	P
rs7566605	C	−0.03 (−0.46; 0.39)	0.88	0.004 (−0.018; 0.023)	0.65
rs10185316	G	0.02 (−0.37; 0.41)	0.92	−0.006 (−0.024; 0.011)	0.49
rs4848492	C	0.01 (−0.48; 0.51)	0.95	−0.008 (−0.029; 0.013)	0.44
rs13428113	C	−0.003 (−0.36; 0.36)	0.99	0.009 (−0.008; 0.025)	0.32
rs1352083	T	−0.06 (−0.45; 0.34)	0.77	−0.011 (−0.020; 0.007)	0.23
rs12464355	G	0.47 (−1.44; 2.39)	0.62	−0.03 (−0.11; 0.05)	0.51
rs17528324	A	−0.16 (−1.83; 1.50)	0.85	0.003 (−0.063; 0.069)	0.92
rs889904	G	0.10 (−0.27; 0.47)	0.6	0.001 (−0.016; 0.018)	0.93
rs10490624	G	−0.04 (−0.62; 0.54)	0.89	0.011 (−0.017; 0.039)	0.44
rs13409050	G	0.4 (0.03; 0.80)	0.07	0.02 (0.01; 0.03)	0.02
rs9308762	C	0.12 (−0.43; 0.68)	0.66	−0.006 (−0.031; 0.018)	0.61
Whites (N=2,175)
rs7566605	C	0.19 (−0.09; 0.47)	0.2	−0.003 (−0.019; 0.012)	0.69
rs10185316	G	0.10 (−0.17; 0.37)	0.48	−0.005 (−0.019; 0.010)	0.51
rs4848492	C	0.20 (−0.30; 0.69)	0.44	−0.014 (−0.043; 0.015)	0.35
rs13428113	C	−0.18 (−0.45; 0.08)	0.17	0.009 (−0.005; 0.023)	0.18
rs1352083	T	0.07 (−0.22; 0.37)	0.62	−0.003 (−0.018; 0.013)	0.75
rs12464355	G	−0.26 (−0.68; 0.16)	0.23	0.017 (−0.010; 0.044)	0.22
rs17528324	A	−0.07 (−0.56; 0.42)	0.77	−0.005 (−0.032; 0.023)	0.74
rs889904	G	−0.004 (−0.26; 0.26)	0.98	−0.008 (−0.021; 0.006)	0.26
rs10490624	G	−0.15 (−0.54; 0.23)	0.44	0.004 (−0.018; 0.027)	0.7
rs13409050	G	0.002 (−0.47; 0.48)	0.99	0.023 (−0.002; 0.048)	0.08
rs9308762	C	0.08 (−0.31; 0.46)	0.69	−0.006 (−0.027; 0.014)	0.55
Table 4b. Age-dependent association of selected INSIG2 tagSNPs with HDL-cholesterol levels in the total cohort by race.
African-Americans (N=2,129)
SNP	Reference allele	Difference^a in trait value (95% CI) at age 18 per copy of reference allele	P	Change^a in trait value (95% CI) par year of age per copy of reference allele	P
rs7566605	C	−0.07 (−0.93; 0.80)	0.88	0.006 (−0.043; 0.055)	0.81
rs10185316	G	0.27 (−0.53; 1.08)	0.51	−0.024 (−0.068; 0.020)	0.29
rs4848492	C	0.21 (−0.76; 1.18)	0.67	0.02 (−0.03; 0.07)	0.43
rs13428113	C	−0.47 (−1.22; 0.28)	0.22	0.008 (−0.030; 0.047)	0.66
rs1352083	T	−0.05 (−0.79; 0.88)	0.91	−0.015 (−0.061; 0.030)	0.5
rs12464355	G	−0.48 (−3.84; 2.87)	0.78	0.02 (−0.12; 0.16)	0.78
rs17528324	A	1.01 (−1.63; 3.65)	0.45	0.03 (−0.14; 0.20)	0.76
rs889904	G	−0.65 (−1.43; 0.13)	0.1	0.025 (−0.017; 0.066)	0.24
rs10490624	G	0.50 (−0.76; 1.77)	0.44	−0.012 (−0.076; 0.051)	0.7
rs13409050	G	0.72 (−0.16; 1.60)	0.11	0.014 (−0.036; 0.063)	0.59
rs9308762	C	−0.41 (−1.48; 0.67)	0.46	−0.012 (−0.068; 0.043)	0.66
Whites (N=2,175)
rs7566605	C	0.20 (−0.93; 0.53)	0.59	−0.002 (−0.042; 0.037)	0.9
rs10185316	G	−0.7 (−1.4; 0.01) −0.6 (−1.3; 0.06)^*	0.05 0.07	−0.03 (−0.07; 0.01) −0.04 (−0.07; 0.00)^*	0.09 0.05
rs4848492	C	0.22 (−1.03; 1.47)	0.73	0.06 (−0.005; 0.118)	0.07
rs13428113	C	0.56 (−0.14; 1.28)	0.11	0.013 (−0.025;0.051)	0.49
rs1352083	T	−0.19 (−0.98; 0.59) −0.14 (−0.88; 0.60)^*	0.62 0.71	−0.07 (−0.11; −0.02) −0.07 (−0.11; −0.03)^*	0.002 0.0007
rs12464355	G	−0.99 (−0.46; 2.43)	0.18	−0.046 (−0.115; 0.023)	0.19
rs17528324	A	−1.48 (−3.06; 0.10)	0.06	0.07 (−0.01; 0.15)	0.09
rs889904	G	0.11 (−0.56; 0.80)	0.74	0.02 (−0.01; 0.06)	0.27
rs10490624	G	−0.74 (−1.91; 0.44)	0.22	0.012 (−0.051; 0.076)	0.7
rs13409050	G	0.13 (−1.28; 1.54)	0.85	−0.09 (−0.16; −0.02)	0.01
rs9308762	C	0.09 (−0.83; 1.02)	0.84	0.053 (0.004; 0.103)	0.03

Models were adjusted for examination, sex, and field center.

expressed in kg/m²

Models were adjusted for examination, sex, end field center.

also adjusted for time-dependent BMI and use of lipid-lowering medication;

expressed in mg/dL