Table 7.

Study Measurements and Sub-Studies

Physical measurements and tests

Height, weight, and body mass index

Body composition

Resting and exercise heart rate

Resting and exercise blood pressure

Resting and exercise 12-lead ECG

Peak and submaximal oxygen consumption

Ventilatory threshold

Mechanistic physiological measurements

Resting and exercise echocardiogram

Skeletal muscle function (fiber type distribution, oxidative capacity, and muscular strength)

Pulmonary function

Hemoglobin concentration

Resting and exercise oxygen saturation

Each intervention (exercise or attention control) session: heart rate, blood pressure, oxygen saturation, RPE

Patient-reported outcomes (questionnaire-based)

Medications

Quality of life

Fatigue

Dyspnea

Depression

Adverse events (Common Terminology Criteria for Adverse Events; CTCAE v.4.0)

Substudies

Genetic studies to examine differences to exercise stimulus

Predictors of exercise adherence

Pilot studies for exercise-induced changes in peripheral gene expression