Skip to main content
. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Neurobiol Aging. 2009 Dec 1;32(10):1818–1826. doi: 10.1016/j.neurobiolaging.2009.10.017

FIG. 4.

FIG. 4

RACK1 expression restores the Aβ-induced loss of muscarinic regulation of sIPSC amplitudes in vivo. A,C, Immunocytochemical images of cortical slices from rats stereotaxically injected with GFP (A) or GFP-RACK1 (C) Sindbis viruses. B,D, Cumulative plots of the distribution of sIPSC amplitudes showing the effect of carbachol (CCh, 20 μM) in cortical neurons from A (1 μM)-injected rats that were infected with GFP (B) or GFP-RACK1 (D) Sindbis viruses. Inset: representative sIPSC traces. Scale bars: 30 pA, 1s. E,F, Cumulative data (mean ± SEM) showing the percent increase of sIPSC amplitude (E) or frequency (F) by carbachol in cortical neurons (from Aβ-injected rats) overexpressing GFP or GFP-RACK1. *: p < 0.01, ANOVA, compared to the effect of carbachol in the control condition (−).