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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: Brain Res. 2010 Feb 1;1323:161–173. doi: 10.1016/j.brainres.2010.01.067

Figure 5.

Figure 5

Cytochrome oxidase histochemistry (background stain) with amyloid precursor protein (APP) immunohistochemistry (black) in uninjured sham (A; −3.24 mm from bregma) and 2d brain-injured (B–E) rats demonstrate the extent of axonal pathology across the subcortical white matter (B; −4.56 mm from bregma), superior thalamic radiation (C; −4.56 mm from bregma), internal capsule (D; −1.56 mm from bregma) and fimbria of the hippocampus (E; −3.48 mm from bregma). Axonal injury is identified by APP-positive immunoreactivity and swollen axonal segments or terminal bulbs. Scattered pathology is evident in the low magnification images and the high magnification insets. All scale bars are 10 µm.