Table 3.
Odds ratios for the metabolic syndrome associated with body mass index and the mediating role of adipocytokines
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| BMI | ||||||||
| 18.5–24.9 kg/m2 (ref) (n=268) | 1 | 1 | 1 | |||||
| 25–29.9 kg/m2 (n=440) | 2.50 | 1.67–3.74 | 2.03 | 1.21–3.39 | 2.06 | 1.22–3.47 | ||
| ≥ 30 kg/m2 (n=236) | 8.73 | 5.64–13.50 | 5.62 | 3.12–10.15 | 5.27 | 2.89–9.59 | ||
| Cytokines * | ||||||||
| Log CRP (mg/L) | 1.17 | 0.95–1.45 | 1.12 | 0.90–1.39 | 1.08 | 0.87–1.35 | ||
| Log IL-6 (pg/mL) | 1.00 | 0.81–1.23 | 1.01 | 0.82–1.25 | 0.97 | 0.78–1.21 | ||
| Log IL-1ra (pg/mL) | 1.38 | 1.10–1.73 | 1.34 | 1.07–1.67 | 1.52 | 1.19–1.95 | ||
| Log IL-18 (pg/mL) | 1.15 | 0.95–1.39 | 1.17 | 0.96–1.42 | 1.17 | 0.95–1.43 | ||
| Log TNF-α R1 (pg/mL) | 1.27 | 1.02–1.57 | 1.27 | 1.01–1.58 | 1.22 | 0.97–1.54 | ||
| Adipokines * | ||||||||
| Log Adiponectin (ng/mL) | 0.56 | 0.46–0.67 | 0.54 | 0.44–0.66 | 0.54 | 0.44–0.66 | ||
| Log Leptin (ng/mL) | 1.85 | 1.47–2.34 | 1.29 | 0.99–1.68 | 1.26 | 0.96–1.65 | ||
| Log Resistin (ng/mL) | 1.01 | 0.83–1.22 | 1.03 | 0.84–1.26 | 1.01 | 0.82–1.24 | ||
Adipocytokines are presented as standardized values and OR indicates odds per standard deviation (SD) increment in adipocytokine. Model 1 included BMI, age and sex. Model 2 included adipocytokines, age and sex. Model 3 included BMI, adipocytokines, age and sex. Model 4 included BMI, adipocytokines, age, sex, education, physical activity, smoking and alcohol consumption.
OR = odds ratio; CI = confidence interval; BMI = body mass index; CRP = C-reactive protein (standard deviation SD=1.05 mg/L); IL-6 = interleukin 6 (SD=0.84 pg/mL); IL-1ra = interleukin 1 receptor antagonist (SD=0.57 pg/mL); IL-18 = interleukin 18 (SD=0.35 pg/mL), TNF-α R1 = tumor necrosis factor- α receptor 1 (SD=0.35 pg/mL). Adiponectin SD=0.73 ng/mL; Leptin SD=1.04 ng/mL; Resistin SD=0.45 ng/mL.