Table 4.

Odds ratios for the metabolic syndrome associated with waist circumference and the mediating role of adipocytokines ^*

	Model 1		Model 2		Model 3		Model 4
	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
Waist circumference †
Normal (ref) (n=277)	1				1		1
Increased (n=285)	2.10	1.23–3.58			1.58	0.82–3.05	1.45	0.74–2.85
Large (n=382)	4.34	2.60–7.26			3.25	1.64–6.44	2.89	1.42–5.86
Cytokines ‡
Log CRP (mg/L)			1.00	0.78–1.28	0.95	0.74–1.22	0.87	0.67–1.14
Log IL-6 (pg/mL)			1.07	0.83–1.36	1.08	0.84–1.39	1.01	0.77–1.31
Log IL-1ra (pg/mL)			1.42	1.08–1.86	1.40	1.07–1.83	1.73	1.28–2.33
Log IL-18 (pg/mL)			1.21	0.96–1.52	1.21	0.96–1.53	1.22	0.96–1.56
Log TNF-α R1 (pg/mL)			1.21	0.95–1.55	1.21	0.95–1.56	1.17	0.90–1.51
Adipokines ‡
Log Adiponectin (ng/mL)			0.50	0.40–0.62	0.50	0.41–0.63	0.49	0.39–0.62
Log Leptin (ng/mL)			1.42	1.08–1.86	1.14	0.85–1.54	1.08	0.79–1.48
Log Resistin (ng/mL)			1.04	0.83–1.30	1.05	0.84–1.32	1.01	0.79–1.29

^*Metabolic syndrome defined without waist circumference component.

^†Normal < 80 cm in women and < 94 cm in men; Increased 80–87cm in women and 94–101 cm in men; Large ≥ 88 cm in women and ≥ 102 cm in men.

^‡Adipocytokines are presented as standardized values and OR indicates odds per standard deviation (SD) increment in adipocytokine.

Model 1 included BMI, age and sex. Model 2 included adipocytokines, age and sex. Model 3 included BMI, adipocytokines, age and sex. Model 4 included BMI, adipocytokines, age, sex, education, physical activity, smoking and alcohol consumption.

OR = odds ratio; CI = confidence interval; CRP = C-reactive protein (standard deviation SD=1.05 mg/L); IL-6 = interleukin 6 (SD=0.84 pg/mL); IL-1ra = interleukin 1 receptor antagonist (SD=0.57 pg/mL); IL-18 = interleukin 18 (SD=0.35 pg/mL), TNF-α R1 = tumor necrosis factor- α receptor 1 (SD=0.35 pg/mL). Adiponectin SD=0.73 ng/mL; Leptin SD=1.04 ng/mL; Resistin SD=0.45 ng/mL.