Table 5.

Odds ratios for the metabolic syndrome according to the number of dysregulated adipocytokines among non-obese and obese persons

	Non-obese				Obese
	Model 1		Model 2		Model 1		Model 2
	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
Number of cytokines *
0 (ref)	1		1		1		1
1	1.52	0.90–2.55	1.17	0.66–2.05	2.39	0.99–5.76	3.15	1.18–8.44
2	2.00	1.17–3.44	1.66	0.93–2.96	3.57	1.42–9.00	4.39	1.55–12.43
3	3.28	1.83–5.87	2.73	1.46–5.09	3.36	1.31–8.61	3.73	1.26–11.02
4–5	3.76	1.91–7.42	2.47	1.20–5.08	5.97	2.24–15.94	6.97	2.32–20.93
Log HOMA-IR			3.26	2.24–4.75			4.37	2.35–8.15
p for trend †	<.0001		0.001		0.001		0.002
Number of adipokines ‡
0 (ref)	1		1		1		1
1	1.28	0.83–1.95	1.25	0.79–1.98	1.25	0.61–2.54	0.83	0.36–1.88
2–3	3.13	1.93–5.07	2.89	1.71–4.87	2.03	0.97–4.26	1.32	0.58–3.04
Log HOMA-IR			3.17	2.17–4.62			4.39	2.41–8.01
p for trend †	<.0001		0.0002		0.04		0.35

^*Number of cytokines in the highest tertile (CRP, IL-6, IL-1ra, IL-18, TNF-α R1).

^†Trend test is examining the linearity of the ORs for number of cytokines and adipokines.

^‡Number of adipokines in the highest tertile (leptin, resistin) and lowest tertile (adiponectin). Model 1 included adipocytokines, age and sex. Model 2 included adipocytokines,HOMA-IR, age, sex, education, physical activity, smoking and alcohol consumption. OR = odds ratio; CI = confidence interval; HOMA-IR = homeostasis model assessment indicating insulin resistance.