Table 6.
Strongest meta-analysis findings for Narrow phenotype (All, Male or Female subjects)
| R2 | --GAIN-MDD-- | --GenRED-- | --STAR*D-- | Meta-analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Band | SNP | BP | A1/ A2 |
All Frq |
GAIN | GR | SD | OR | P | OR | P | OR | P | OR | P | Annotation |
| ALL-NARROW | ||||||||||||||||
|
| ||||||||||||||||
| 18q22.1 | rs17077540 | 63436259 | A/G | 0.110 | 0.331 | 0.859 | 0.649 | 1.250 | 2.93E-01 | 1.610 | 1.83E-07 | 1.302 | 3.94E-02 | 1.481 | 6.04E-07 | mRNA BC053410 (LOC643542);DSEL (up) |
| 5p13.2 | rs270592 | 38102343 | A/G | 0.570 | 0.996 | 0.989 | 0.991 | 1.170 | 3.62E-02 | 1.320 | 2.49E-06 | 1.150 | 3.56E-02 | 1.223 | 1.88E-06 | GDNF (220kb up) |
| Xp21.1 | rs2405829 | 32364267 | A/G | 0.540 | 0.960 | 0.960 | 0.960 | 1.280 | 5.50E-04 | 1.130 | 1.87E-02 | 1.190 | 2.10E-03 | 1.180 | 3.84E-06 | DMD |
| 6p22.1 | rs6930508 | 27161121 | C/T | 0.560 | 0.988 | 0.999 | 0.999 | 1.240 | 5.41 E-03 | 1.180 | 4.19E-03 | 1.231 | 1.55E-03 | 1.213 | 4.73E-06 | histone 2/4 gene cluster; GUSBL1 (up,noncoding) |
| 10p11.23 | rs1612122 | 29331904 | A/T | 0.480 | 0.959 | 0.953 | 0.923 | 1.280 | 1.48E-03 | 1.200 | 2.38E-03 | 1.176 | 1.78E-02 | 1.218 | 5.39E-06 | |
| 3p26.1 | rs9870680 | 7504555 | C/T | 0.433 | 0.847 | 1.000 | 1.000 | 1.287 | 1.97E-03 | 1.220 | 4.76E-04 | 1.134 | 5.13E-02 | 1.211 | 5.56E-06 | GRM7 |
| 3q25.1 | rs1456139 | 152123994 | A/G | 0.610 | 0.999 | 0.845 | 0.839 | 1.180 | 1.99E-02 | 1.240 | 9.11E-04 | 1.242 | 3.40E-03 | 1.219 | 7.92E-06 | CLRN1 (dwn) |
| CRLF1; up:C19orf50,UBA52,C19orf60; | ||||||||||||||||
| 19p13.11 | rs7249956 | 18576203 | A/C | 0.770 | 0.893 | 0.898 | 0.732 | 1.270 | 1.41E-02 | 1.260 | 1.69E-03 | 1.316 | 2.77E-03 | 1.277 | 8.11E-06 | dwn:TMEM59L,KLHL26 |
| 12q23.3 | rs1895943 | 106764962 | A/C | 0.040 | 0.989 | 1.000 | 0.803 | 1.350 | 6.85E-02 | 1.600 | 1.67E-04 | 1.602 | 4.03E-03 | 1.519 | 8.70E-06 | CpG island at 106.76 Mb; PRDM4 (85kb up) |
| 6q22.1 | rs1855625 | 114535864 | G/T | 0.684 | 0.998 | 1.000 | 0.996 | 1.110 | 2.00E-01 | 1.283 | 9.00E-05 | 1.279 | 7.64E-04 | 1.226 | 9.34E-06 | HS3ST5,−45130 |
| 1p32.2 | rs6694643 | 57121995 | A/T | 0.120 | 0.990 | 1.000 | 0.885 | 1.510 | 7.88E-05 | 1.210 | 1.16E-02 | 1.189 | 8.94E-02 | 1.294 | 9.50E-06 | C8A,within; C8B,45475 |
|
| ||||||||||||||||
| MALES-NARROW | ||||||||||||||||
|
| ||||||||||||||||
| 3p14.1 | rs11710109 | 66836364 | C/T | 0.380 | 0.990 | 0.991 | 0.843 | 1.580 | 2.46E-03 | 1.500 | 6.06E-05 | 1.397 | 2.70E-03 | 1.483 | 6.54E-08 | |
| 11p15.1 | rs389967 | 16831186 | A/G | 0.100 | 0.947 | 1.000 | 0.975 | 1.470 | 8.23E-02 | 1.710 | 2.33E-04 | 1.761 | 1.64E-04 | 1.675 | 5.75E-07 | PLEKHA7,within |
| 4q23 | rs10007831 | 99911315 | C/T | 0.520 | 0.977 | 0.984 | 0.684 | 1.600 | 1.75E-03 | 1.340 | 3.39E-03 | 1.493 | 1.13E-03 | 1.441 | 9.64E-07 | |
| 10q11.21 | rs7079573 | 44720412 | A/G | 0.540 | 0.920 | 0.882 | 0.624 | 1.430 | 2.46E-02 | 1.380 | 2.42E-03 | 1.473 | 2.58E-03 | 1.418 | 9.53E-06 | KSP37,−6357 check dir |
|
| ||||||||||||||||
| FEMALES-NARROW | ||||||||||||||||
|
| ||||||||||||||||
| 5p13.2 | rs270584 | 38110611 | A/C | 0.560 | 0.999 | 1.000 | 1.000 | 1.200 | 3.47E-02 | 1.390 | 1.64E-05 | 1.421 | 1.53E-04 | 1.321 | 3.71E-07 | GDNF (230kb up) |
| 2q22.1 | rs6711718 | 137123482 | C/T | 0.390 | 1.000 | 0.997 | 0.749 | 1.400 | 1.14E-04 | 1.200 | 7.23E-03 | 1.295 | 1.33E-02 | 1.293 | 1.71E-06 | |
| 6q25.2 | rs644377 | 153260377 | A/T | 0.420 | 1.000 | 1.000 | 1.000 | 1.280 | 5.08E-03 | 1.330 | 1.44E-04 | 1.256 | 1.13E-02 | 1.294 | 1.91E-06 | |
| 4q28.1 | rs2203374 | 128653784 | C/G | 0.790 | 0.801 | 0.814 | 0.770 | 1.390 | 1.36E-02 | 1.560 | 5.91E-05 | 1.400 | 1.20E-02 | 1.461 | 2.71E-06 | INTU (120kb up) |
| 12q14.1 | rs7977950 | 60513443 | C/T | 0.120 | 0.994 | 1.000 | 0.991 | 1.230 | 9.52E-02 | 1.400 | 1.30E-03 | 1.824 | 1.01E-06 | 1.421 | 3.40E-06 | FAM19A2,within |
| 11q13.4 | rs17133921 | 74712634 | A/G | 0.060 | 1.000 | 1.000 | 1.000 | 1.550 | 3.77E-03 | 1.550 | 3.47E-03 | 1.643 | 1.96E-03 | 1.571 | 5.29E-06 | ARRB1,within |
| 15q25.3 | rs11634319 | 84224912 | C/T | 0.760 | 1.000 | 1.000 | 0.829 | 1.450 | 1.94E-03 | 1.340 | 1.98E-03 | 1.353 | 1.40E-02 | 1.385 | 5.67E-06 | KLHL25 (86kb up) |
| 4q34.3 | rs346101 | 179841206 | A/G | 0.510 | 0.991 | 0.989 | 0.886 | 1.330 | 1.56E-03 | 1.160 | 5.59E-02 | 1.508 | 1.70E-05 | 1.289 | 6.01E-06 | |