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The role of Nrf2 in Phase 2 enzyme induction by dithiolethiones. NBT-II cells were treated with control RNAi or Nrf2 RNAi for 48 h, followed by treatment with vehicle or compounds 11 or 19 at 25 μM for 24 h. The cells were then harvested for Western blot analysis of Nrf2 and Phase 2 enzymes. GAPDH was used as a loading control.
