Table 1.
Baseline clinical characteristics of control women (N=42) and women with primary ovarian insufficiency (POI) (N=97)
| Characteristic | Control Median (IQR) or N(%) | POI Median (IQR) or N(%) | P value |
|---|---|---|---|
| Age | 37.0 (31.0, 42.0) | 34.0 (28.0, 36.0) | 0.003 |
| BMI | 22.7 (21.0, 24.7) | 23.5 (20.9, 26.0) | 0.158 |
| Age at Menarche | 13.0 (12.0, 14.0) | 13.0 (12.0, 14.0) | 0.335 |
| Race % | 0.119 | ||
| Asian | 6 (14) | 6 (6) | |
| African American | 7 (17) | 11 (11) | |
| Hispanic | 3 (7) | 3 (3) | |
| Caucasian | 26 (62) | 77 (79) | |
| FSH (IU/L) | 8.0 (7.0, 11.0) | 81.0 (51.0, 111.0) | <0.001 |
| LH (IU/L) | ND | 49.0 (35.0, 68.0) | -------- |
| Estradiol (pg/mL) | 36.3 (28.0, 57.0) | 27.0 (20.0, 40.4) | 0.019 |
| Progesterone (ng/mL) | ND | 0.5 (0.3, 0.7) | -------- |
| Endometrial stripe (mm) | 4.0 (3.0, 6.0) | 2.0 (1.0, 3.0) | <0.001 |
| Right ovarian volume (cm3) | 6.9 (5.8, 8.9) | 1.4 (0.7, 2.6) | <0.001 |
| Left ovarian volume (cm3) | 6.6 (4.4, 8.7) | 1.4 (0.5, 2.4) | <0.001 |
| Largest follicle (mm) | 9.0 (8.0, 11.0) | 6.6 (2.3, 12.8) | 0.003 |
| Age at onset of menstrual irregularity | N/A | 28.4 (18.2, 32.9) | -------- |
| Age at POI diagnosis | N/A | 31.9 (25.3, 34.2) | -------- |
| Time since POI diagnosis (months) | N/A | 20.3 (5.8, 50.6) | -------- |
IQR = Interquartile range, ND = Not done, NA = Not applicable