Table 2.

Baseline comparison of women with primary ovarian insufficiency segregated by the absence (N=52) or presence (N=43) of a follicle of 8mm in diameter or greater and after statistical adjustment of hormone values for age, age of onset of menstrual irregularity, age at diagnosis, and time since diagnosis.

Factor	<8mm follicle Median (IQR) or N (%)	≥8 mm follicle Median (IQR) or N (%)	P value	Adjusted P value
Age	31.5 (26.0,36.0)	34.0 (32.0,36.0)	0.063
BMI	24.4 (21.5,27.9)	22.6 (20.6, 25.4)	0.107
Age at menarche	13.0 (12.0, 13.0)	13.0 (12.0, 14.0)	0.976
Age at onset of menstrual irregularity	26.0 (16.0, 31.0)	31.5 (25.2, 33.3)	0.009
Age at POI diagnosis	29.0 (21.5, 33.4)	33.5 (30.8, 34.7)	0.002
Time since POI diagnosis (months)	27.4 (6.4, 74.9)	15.2 (4.8, 30.1)	0.029
Serum estradiol (pg/mL)	23.0 (20.0, 32.5)	39.6 (21.9, 80.9)	<0.001	0.002
Serum progesterone (ng/mL)	0.5 (0.2, 0.6)	0.6 (0.5, 0.8)	0.002	0.004
FSH (IU/L)	93.0 (70.0, 115.0)	57.0 (33.0, 106.0)	0.001	0.002
LH (IU/L)	56.0 (42.0, 68.0)	37.5 (23.0, 68.0)	0.019	0.013
History of smoking	3 (6)	5 (12)	0.461
History of primary ovarian insufficiency in family	9 (17)	12 (28)	0.227
Adrenal autoantibodies	0 (0)	3 (7)	0.089
History of thyroid disease	7 (14)	7 (16)	0.776
Race			0.424
Asian	3 (6)	3 (7)
African American	7 (13)	4 (9)
Hispanic	3(6)	0 (0)
Caucasian	39 (75)	36 (84)