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Effect of systemic metformin on adipokine levels
| Treatment group | Leptin (pg/ml) | Resistin (pg/ml) |
|---|---|---|
| Control | 405.6 ± 87.74 | 1166 ± 84.89 |
| Control + Met | 382.0 ± 67.81 | 832.8 ± 65.34** |
| HED | 1174 ± 163.1** | 4803 ± 624.9** |
| HED + Met | 1243 ± 187.5 | 4462 ± 621.1 |
Blood samples from each animal were evaluated for adipokine levels Leptin—Control versus HED; **P = 0.0061
Resistin—Control versus Control + Met, **P = 0.0095; Control versus HED; **P = 0.0014
