Table 2.
Multivariate relative risks (RR) and 95% confidence intervals (CI) of epithelial ovarian cancer according to WHR, BMI, waist and hip circumference in the NHS, NHSII and pooled analysis.
| NHS | NHS II | NHS and NHS II | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Person-years | Multivariatea RR (95% CI) |
Cases | Person-years | Multivariatea RR (95% CI) |
Cases | Person-years | Multivariatea RR (95% CI) |
|
| WHR | |||||||||
| < 0.73 | 54 | 138418 | 1.0 (REF) | 11 | 112377 | 1.0 (REF) | 65 | 253759 | 1.0 (REF) |
| 0.73-≤0.75 | 35 | 121977 | 0.70 (0.45–1.07) | 9 | 102586 | 0.99 (0.41–2.40) | 44 | 227280 | 0.74 (0.50–1.09) |
| 0.76-≤0.79 | 70 | 153879 | 1.06 (0.74–1.52) | 13 | 128547 | 1.04 (0.46–2.36) | 83 | 285718 | 1.04 (0.75–1.45) |
| 0.80-≤0.83 | 65 | 122078 | 1.23 (0.85–1.79) | 6 | 85560 | 0.70 (0.25–1.91) | 71 | 209960 | 1.13 (0.80–1.61) |
| ≥ 0.84 | 57 | 151189 | 0.78 (0.52–1.16) | 13 | 103364 | 1.08 (0.46–2.55) | 70 | 257367 | 0.81 (0.56–1.16) |
| P trendb | 0.58 | 0.98 | 0.63 | ||||||
| P-heterogeneityc=0.82 | |||||||||
| Waist, inches | |||||||||
| < 28 | 55 | 135883 | 1.0 (REF) | 12 | 1.0 (REF) | 67 | 292656 | 1.0 (REF) | |
| 28-<30 | 57 | 143263 | 0.91 (0.62–1.33) | 8 | 115526 | 0.86 (0.35–2.14) | 65 | 261747 | 0.91 (0.64–1.29) |
| 30-<32 | 52 | 121716 | 0.94 (0.62–1.41) | 4 | 86734 | 0.52 (0.16–1.66) | 56 | 210725 | 0.89 (0.61–1.30) |
| 32-<35 | 52 | 142957 | 0.76 (0.49–1.18) | 16 | 81892 | 2.15 (0.91–5.05) | 68 | 227091 | 0.90 (0.61–1.33) |
| ≥ 35 | 67 | 149534 | 0.99 (0.59–1.64) | 12 | 97929 | 1.12 (0.35–3.57) | 79 | 250087 | 1.00 (0.62–1.58) |
| P trendb | 0.35 | 0.27 | 0.65 | ||||||
| P-heterogeneityc=0.16 | |||||||||
| Hip, inches | |||||||||
| < 37 | 64 | 130343 | 1.0 (REF) | 10 | 145488 | 1.0 (REF) | 74 | 279831 | 1.0 (REF) |
| 38-<38.5 | 61 | 146285 | 0.78 (0.54–1.12) | 7 | 117248 | 0.86 (0.35–2.13) | 68 | 266595 | 0.80 (0.57–1.12) |
| 38.5-<40.5 | 59 | 158808 | 0.66 (0.45–0.97) | 8 | 104826 | 0.52 (0.16–1.66) | 67 | 266310 | 0.71 (0.50–1.03) |
| 40.5-<43 | 42 | 120409 | 0.57 (0.36–0.90) | 15 | 70997 | 2.14 (0.91–5.04) | 57 | 193259 | 0.74 (0.49–1.12) |
| ≥43-≤65 | 55 | 132718 | 0.67 (0.39–1.17) | 12 | 94309 | 1.12 (0.35–3.57) | 67 | 229565 | 0.76 (0.46–1.26) |
| P trendb | 0.05 | 0.05 | 0.33 | ||||||
| P-heterogeneityc<0.01 | |||||||||
| BMI, kg/m2 | |||||||||
| < 21.0 | 102 | 383568 | 1.0 (REF) | 23 | 301288 | 1.0 (REF) | 125 | 696833 | 1.0 (REF) |
| 21.0-<23 | 138 | 470735 | 1.03 (0.80–1.33) | 17 | 314319 | 0.67 (0.36–1.26) | 155 | 798639 | 0.97 (0.77–1.23) |
| 23-<25 | 156 | 458994 | 1.12 (0.87–1.44) | 12 | 268800 | 0.51 (0.25–1.03) | 168 | 739738 | 1.02 (0.81–1.29) |
| 25-<30 | 204 | 661749 | 0.96 (0.75–1.22) | 38 | 366831 | 1.13 (0.66–1.92) | 242 | 1047619 | 0.96 (0.77–1.19) |
| ≥30 | 132 | 370816 | 1.11 (0.85–1.45) | 40 | 285650 | 1.36 (0.80–2.33) | 177 | 673930 | 1.12 (0.89–1.42) |
| P trendb | 0.72 | 0.01 | 0.29 | ||||||
| P-heterogeneityc=0.04 | |||||||||
Multivariate analyses adjusted for age at menarche (continuous), parity (continuous), duration of oral contraceptive use (continuous), tubal ligation history (yes, no), height (< 1.6, 1.6-<1.65, 1.65-<1.7, 1.7-<1.75, and ≥ 1.75 meters), family history of breast or ovarian cancer (yes, no), caffeine intake (quintiles in mg/day), hysterectomy (yes, no), postmenopausal hormone use/menopausal status (premenopausal, postmenopausal/never PMH use, postmenopausal/past PMH use, postmenopausal/current PMH use, postmenopausal/missing PMH use, and missing/unknown menopausal status) and BMI (continuous) in the WHR analysis, waist (continuous) and BMI (continuous) in the hip analysis, and hip (continuous) and BMI (continuous) in the waist analysis.
P value from multivariate model with WHR, BMI, waist or hip using the quintile median a continuous variable.
P-heterogeneity by cohort assessed using the DerSimonian and Laird random effects model.