Table 2.
Characteristics of participants with MCI (cases) and without MCI (controls). Mayo Clinic Study of Aging 2004-2006
| Variable | All subjects (n = 1969) | MCIa cases | Normal cognition (n = 1640) | p valueb | ||
|---|---|---|---|---|---|---|
| Amnestic (n = 241) | Non-amnestic (n = 88) | All MCI (n = 329) | ||||
| Age, median (Q1, Q3) | 80.4 (75.4, 84.0) | 82.7 (79.0, 86.0) | 82.5 (78.4, 85.4) | 82.7 (79.0, 85.8) | 79.6 (75.1, 83.6) | <0.0001 |
| Sex, n (% male) | 1002 (50.9) | 150 (62.2) | 42 (47.7) | 192 (58.4) | 810 (49.4) | 0.003 |
| Education (years) | 13 (12, 16) | 12 (12, 16) | 12 (12, 14) | 12 (12, 15) | 13 (12, 16) | <0.0001 |
| Stroke or TIA, (n, %) | 346 (17.6) | 61 (25.3) | 30 (34.1) | 91 (27.7) | 255 (15.5) | <0.0001 |
| Hypertension, (n, %) | 1388 (70.5) | 166 (68.9) | 68 (77.3) | 234 (71.1) | 1154 (70.4) | 0.795 |
| Diabetes, (n, %) | 356 (18.1) | 44 (18.3) | 22 (25.0) | 66 (20.1) | 290 (17.7) | 0.309 |
| Cigarette smoking, (n, %) | 970 (49.3) | 122 (50.6) | 43 (48.9) | 165 (50.2) | 805 (49.1) | 0.731 |
| Depression, (n, %) | 268 (13.6) | 60 (24.9) | 26 (29.5) | 86 (26.1) | 182 (11.1) | <0.0001 |
| BMI, median (Q1, Q3) | 27.2 (24.3, 30.3) | 26.8 (24.0, 29.7) | 27.4 (24.3, 30.1) | 26.9 (24.1, 29.8) | 27.3 (24.4, 30.5) | 0.089 |
| ApoE ε3/4 ApoE ε4/4c | 423 (23.1) | 70 (30.8) | 19 (22.6) | 89 (29.2) | 334 (21.9) | 0.006 |
MCI = mild cognitive impairment; TIA = transient ischemic attack; BMI = body mass index.
a
A consensus diagnosis of mild cognitive impairment.
b
p value for comparison of subjects with and without MCI; these comparisons were not adjusted for potential confounders.
c
Fourteen cases with a-MCI, 4 cases with na-MCI, and 75 cognitively normal subjects had missing ApoE ε4 data. Five cases with a-MCI, 1 case with na-MCI, and 37 cognitively normal subjects with ApoE ε2/4 are not included.