Table 3.
Association of coronary heart disease with MCI and MCI subtypes. Mayo Clinic Study of Aging 2004-2006
| Variable | Normal cognitiona (n, %) | Any MCI (n = 329) | Amnestic MCI (n = 241) | Non-Amnestic MCI (n = 88) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (n, %) | OR (95% CI)b | p value | (n, %) | OR (95% CI)b | p value | (n, %) | OR (95% CI)b | p value | ||
| Coronary heart diseasec | ||||||||||
| Model 1 | 445 (27.1) | 110 (33.4) | 1.14 (0.87-1.49) | 0.33 | 73 (30.3) | 0.94 (0.69-1.28) | 0.68 | 37 (42.0) | 1.93 (1.22-3.06) | 0.005 |
| Model 2 | 445 (27.1) | 110 (33.4) | 1.12 (0.83-1.52) | 0.45 | 73 (30.3) | 0.94 (0.65-1.34) | 0.72 | 37 (42.0) | 1.85 (1.12-3.05) | 0.02 |
| Myocardial infarctiond | ||||||||||
| Model 1 | 128 (7.8) | 29 (8.8) | 0.99 (0.64-1.53) | 0.98 | 23 (9.5) | 1.06 (0.66-1.72) | 0.80 | 6 (6.8) | 0.77 (0.33-1.83) | 0.56 |
| Model 2 | 128 (7.8) | 29 (8.8) | 0.91 (0.55-1.49) | 0.70 | 23 (9.5) | 0.93 (0.53-1.64) | 0.81 | 6 (6.8) | 0.81 (0.33-1.97) | 0.64 |
| CABG or PCI | ||||||||||
| Model 1 | 385 (23.5) | 87 (26.4) | 0.98 (0.74-1.30) | 0.88 | 61 (25.3) | 0.88 (0.63-1.22) | 0.45 | 26 (29.5) | 1.32 (0.81-2.17) | 0.27 |
| Model 2 | 385 (23.5) | 87 (26.4) | 0.92 (0.67-1.27) | 0.62 | 61 (25.3) | 0.86 (0.59-1.25) | 0.42 | 26 (29.5) | 1.17 (0.68-2.00) | 0.58 |
| Angiographic coronary stenosise | ||||||||||
| Model 1 | 331 (75.4) | 88 (80.0) | 1.33 (0.77-2.29) | 0.30 | 59 (76.6) | 1.02 (0.56-1.85) | 0.95 | 29 (87.9) | 3.21 (1.02-10.04) | 0.05 |
| Model 2 | 331 (75.4) | 88 (80.0) | 1.21 (0.65-2.25) | 0.55 | 59 (76.6) | 0.96 (0.48-1.95) | 0.92 | 29 (87.9) | 2.14 (0.68-6.75) | 0.20 |
MCI = mild cognitive impairment; OR = odds ratio; CI = confidence interval; CABG = coronary artery bypass grafting; PCI = percutaneous coronary intervention.
n = 1640 were cognitively normal.
Odds ratio (95% confidence intervals). Model 1 estimates are adjusted for age, sex, and years of education (continuous variables). Model 2 estimates (fully-adjusted model) are adjusted for age, sex, and years of education (continuous variables); diabetes, hypertension, stroke, BMI, depression, dyslipidemia, and ApoE genotype.
CHD defined as definite (validated) myocardial infarction, CABG, PCI, or angiographic coronary stenosis.
Definite myocardial infarction.
Stenosis of ≥50% in at least 1 coronary artery; information was available for 439 cognitively normal, 77 a-MCI, and 33 na-MCI subjects.