Table 4.

Relationships of microscopic lesions to clinical diagnoses of dementia, AD or VaD.

	Any dementia^a, no. of cases/total = 131/190		Alzheimer’s disease^b, no. of cases/total = 84/143		Vascular dementia^c, no. of cases/total = 28/87

	Model 1^d OR (95% CI)	Model 2^e OR (95% CI)	Model 1^d OR (95% CI)	Model 2^e OR (95% CI)	Model 1^d OR (95% CI)	Model 2^e OR (95% CI)
Microscopic vascular
Microinfarcts	0.8 (0.3–2.0)	0.6 (0.2–1.9)	0.6 (0.2–1.7)	0.5 (0.1–1.7)	1.7 (0.6–5.0)	1.4 (0.3–5.7)
Cribriform changes	1.9 (0.7–5.0)	1.7 (0.5–6.2)	1.1 (0.4–3.3)	1.1 (0.3–4.5)	3.0 (0.9–10.1)	1.9 (0.4–8.9)
Cerebral amyloid angiopathy	3.6 (1.5–8.6)^**	1.2 (0.4–3.7)	4.0 (1.6–10.0)^**	1.2 (0.4–3.9)	3.6 (1.2–11.1)^**	1.5 (0.4–5.8)
Neurodegenerative
Braak Staging	2.1 (1.6–2.7)^***	2.1 (1.6–2.9)^***	2.3 (1.7–3.0)^***	2.3 (1.7–3.2)^***	1.8 (1.3–2.5)^***	1.8 (1.2–2.7)^**
Cortical LB	1.9 (0.9–4.1)	1.9 (0.8–4.2)	1.9 (0.9–4.0)	1.8 (0.8–4.1)	2.0 (0.9–4.5)	2.2 (0.9–5.0)

Comparing overall demented to non-demented.

Comparing AD to non-demented excluding VaD and other dementias.

Comparing VaD to non-demented excluding AD and other dementias.

Adjusted for age at death, sex, recruitment group, interval from last evaluation to death in months.

Additionally adjusted for other vascular lesions, Braak NFT stage and cortical Lewy bodies.

^**

p value < 0.05.

^***

p value < 0.001.