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. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Neurobiol Aging. 2008 Nov 8;31(10):1710–1720. doi: 10.1016/j.neurobiolaging.2008.09.011

Table 5.

Relationship of macroscopic vascular lesion score^a to clinical dementia, AD and VaD.

	Any dementia^b		Alzheimer’s disease^c		Vascular dementia^d

	OR (95% CI) Model 1^e	OR (95% CI) Model 2^f	OR (95% CI) Model 1^e	OR (95% CI) Model 2^f	OR (95% CI) Model 1^e	OR (95% CI) Model 2^f
Severity (0–6) (all)^g	1.6 (1.2–2.2)^***	1.6 (1.2–2.3)^**	1.4 (1.0–2.0)^**	1.5 (1.0–2.1)^**	2.1 (1.5–3.1)^***	2.0 (1.4–3.0)^***
0 (n = 102)	1 (reference)	1 (reference)	1 (reference)	1 (reference)	1 (reference)	1 (reference)
1 (n = 26)	2.4 (0.9–6.5)	3.6 (1.1–12.2)	1.6 (0.5–4.7)	2.7 (0.7–10.2)	6.9 (1.4–32.6)^**	8.5 (1.6–45.9)^**
2 (n = 30)	2.6 (0.97–7.1)	2.5 (0.7–8.4)	1.5 (0.5–4.5)	1.4 (0.4–5.5)	13.6 (3.2–58.1)^***	10.1 (2.0–50.8)^**
3 or more (n = 32)	8.4 (2.3–31.1)^***	9.1 (2.1–40.0)^**	4.7 (1.2–18.3)^**	5.6 (1.2–26.3)^**	33.1 (6.0–182.9)^***	27.9 (4.4–175.8)^***

^a

Macroscopic vascular lesions score ranging 0–6 as outlined in Table 1.

^b

Comparing overall demented to non-demented.

^c

Comparing AD to non-demented excluding VaD and other dementias.

^d

Comparing VaD to non-demented excluding AD and other dementias.

^e

Adjusted for age at death, sex, recruitment group, interval from last evaluation to death in months.

^f

Additionally adjusted for other vascular lesions, Braak NFT stage and cortical Lewy bodies.

^g

Using continuous variable for vascular lesion score.

^**

p value < 0.05.

^***

p value < 0.001.