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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Cancer Res. 2010 May 25;70(12):4972–4981. doi: 10.1158/0008-5472.CAN-09-3573

Figure 5. The effects of AZD7762 on patient-derived xenografts in response to gemcitabine and radiation.

Figure 5

Nod-scid mice bearing bilateral, subcutaneous xenografts derived from two different patient pancreatic tumors (patients ‘F’ and ‘J’) (B and C, respectively) were treated with gemcitabine (90 mg/kg), AZD7762 (20 mg/kg), and/or radiation (1.8 Gy/fraction) for 2 cycles as illustrated (A). Data are expressed as the proportion of tumors doubled in volume. Each treatment group contained 6 – 10 mice (12 – 20 tumors).