Table 1.
Tumor doubling time (days)
| Treatment | MiaPaCa-2 | Patient-F | Patient-J |
|---|---|---|---|
| Control | 8 (5,13) | 10.0 (7,10) | 6.5 (6,9) |
| Gem | 12 (10,14) | 33.0* (21,37) | 23.5* (21,26) |
| AZD7762 | 11* (8,21) | 25.5* (20,30) | 26.5* (17,28) |
| IR | 89* (68,nd) | 15.0* (9,18) | 32.5* (16,42) |
| Gem IR | 75* (63,94) | 49.0*π (32,54) | 49.0*π (45,51) |
| AZD7762 IR | >114* (83,nd) | 44.0*π (39,53) | 44.5*π (43,47) |
| Gem AZD7762 | 19*‡ (12,22) | 46.5*‡ (42,52) | 41.0*‡ (37,42) |
| Gem AZD7762 IR | >109*† (88,nd) | 56.0*π (47,62) | 60.5*†π (56,67) |
Data are the median time until tumor volume doubling. The upper and lower limits are indicated in parentheses and nd, where the upper limit could not be determined.
Statistical differences in the time until tumor volume doubling were determined by the log-rank test and are indicated where P<0.05 is indicated versus Control*, Gem‡, Gem IR†, or IRπ.