Table 5.
Summary of suggestive QTLs (parametric approach, interval mapping) for arthritis-related phenotypes (joint diameter) in rats1
| Chr. | Δ Diameter 2 | Model3 | Lod | Location4 | % Var.5 | |
|---|---|---|---|---|---|---|
| Day | Side | |||||
| 2 | 21 | Left | Recessive (−) | 2.9 | D2Mit6 to D2Rat167 (54.0 cM) | 8.1 |
| 24 | Left | Additive (−) | 3.29 | D2Rat26 (63.0 cM) | 8.6 | |
| 7 | 17 | Right | Dominant (+) | 2.46 | D7Rat26 to D7Rat44 (48.0 cM) | 7.4 |
| 21 | Right | Dominant (+) | 2.71 | D7Rat24 to D7Rat99 (63.0 cM) | 9.5 | |
| 24 | Left | Dominant (+) | 2.13 | D7Rat99 (69.0 cM) | 5.7 | |
| 24 | Right | Dominant (+) | 2.09 | D7Rat24 to D7Rat99 (64.0 cM) | 7.1 | |
| 24 | Sum | Dominant (+) | 2.45 | D7Rat99 (69.0 cM) | 6.5 | |
| 8 | 24 | Left | Dominant (+) | 2.42 | D8ARb6 (31.0 cM) | 10.3 |
| 10 | 17 | Left | Dominant (+) | 2.98 | D10Rat155 to D10Rat26 (70.0 cM) | 8.8 |
| 24 | Right | Dominant (+) | 3.38 | D10Rat26 to D10Mgh5 (76.0 cM) | 12.0 | |
| 13 | 17 | Left | Dominant (+) | 2.75 | D13Rat113 (7.0 cM) | 7.3 |
| 21 | Right | Dominant (+) | 2.29 | D13Rat7 (2.0 cM) | 6.1 | |
| 24 | Sum | Dominant (+) | 2.3 | D13Rat7 to D13Rat113 (4.0 cM) | 6.5 | |
| 15 | 17 | Left | Dominant (+) | 2.06 | D15Rat123 to D15Mgh8 (55.0 cM) | 7.5 |
| 17 | 17 | Right | Dominant (−) | 2.69 | D17Rat151 to D17Mgh5 (43.0 cM) | 7.9 |
| 21 | Right | Dominant (−) | 3.22 | D17Rat151 (51.0 cM) | 8.4 | |
| 24 | Right | Dominant (−) | 2.73 | D17Rat151 (51.0 cM) | 7.2 | |
| 20 | 17 | Right | Free (H)6 | 2.83 | D20Rat46 to D20Rat34 (20.0 cM) | 13.7 |
| 24 | Right | Free (H) | 2.92 | D20Rat46 to D20Rat34 (15.0 cM) | 12.5 | |
The QTL analysis was performed on transformed data; thresholds are described in Material and Methods.
Joint diameters of the rear ankles (left, right, or sum of both sides) on day 17, 21, or 24 compared to pre-injection values (calculated differences [Δ]).
Additive, dominant or recessive as well as plus (+) or minus (−) contribution to the trait was defined with respect to the LEW grandparent's allele.
The location on the chromosome where the Lod score peaked is given in parentheses.
Percentage of the genetic variance explained by the QTL.
For some regions the heterozygous genotype was higher than both homozygous genotypes (heterosis effect, H). In these cases the two homozygous genotypes had an identical arthritis phenotype.