Table 1.
Relationship between p53 status and radiosensitivity of human prostate cancer cells.
| Line | p53 Allele | p53 Status | Radiosensitivity (Sf2) |
|---|---|---|---|
| Abbreviations: Wt = wild-type, ND = Not determined, SF2 = Surviving fraction after a 2 Gy dose of irradiation. | |||
| LNCaP | Wt/Wt69 | Wt | 32.6 |
| 22Rv1 | Q331R/Wt70 | Partial function | 30.7 |
| DU145 | P223L/V274F69 | Dominant negative | 80.2 |
| PC-3 | Deleted | Null | 52.2 |
| Patient Q | R282Q | Gain of function33 | ND |