Fundus fluorescence in fixed retinal whole mounts of CFP mouse eyes. Fluorescence of whole-mount retina 6A: Saline, IVI; 6B: NMDA and memantine, IVI; 6C: NMDA, IVI; 6D: NMDA, IVI 1 h after MK801 IP; 6E: KA, IVI; 6F: KA, IVI 1 h after MK801 IP. All eyes are from mice killed 1 day later and fixed for whole-mount histology and fluorescence imaging. Decreased numbers of CFP-positive RGCs are noted from eyes injected with NMDA (6C), KA (6E), and KA+MK801 (6F), whereas fluorescence from eyes injected with NMDA+memantine (6B), and NMDA+MK801 (6D) have intensity comparable to eyes injected with saline (6A). Bar, 200 μm.