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. 2010 May 4;107(20):9222–9227. doi: 10.1073/pnas.1004584107

Fig. 4.

Fig. 4.

Naïve hESCs/hiPSCs share a global transcriptional profile with mESCs. (A) Bar chart showing median expression ratio of pluripotency and lineage-specific marker genes in hESCs and naïve hESCs. Asterisks delineate genes in which the false discovery rate was <0.1 between the naïve and primed group of samples. (B) FACS analysis for surface expression of human and mouse MHC class I alleles. Black graph indicates isotype match control. MFI, median fluorescence intensity. P values using Student's t test indicate significant change (P < 0.01). (C) Cross-species gene expression clustering where mESCs and naïve hESCs formed a distinct group apart from mEpiSCs and hESCs. Legend shown on right with yellow and blue indicating positive and negative correlation, respectively. Gene expression relative abundance was clustered by Spearman correlation and average linkage. Mouse samples are labeled in purple and human samples are labeled in brown.